Abstract: Objective To explore the value of serum procalcitonin and mean platelet volume (MPV) in prediction of prognosis of acute pancreatitis (AP). Methods One hundred and thirty four inpatients with acute pancreatitis were divided into light, moderate, and severe groups according to the criteria of classification, and subsequently divided into the survival group and the death group based on the clinical outcomes. The MPV, serum PCT level and APACHE II score in different severities and clinical outcomes were compared. The ROC curve was used to evaluate the clinical value of PCT, MPV, and combined detections to determine the prognosis of AP. Results With the progression of the disease, the levels of MPV, PCT and the score of APACHE II increased, showing a significant elevation in the cases of death group compared with those of the survival group (P<0.05). A strong positive correlation was noted between MPV and PCT and APACHE II scores (r=0.630, 0.704, P<0.05). ROC curve analysis showed that the sensitivity, specificity, and AUC were 88.9%, 97.2%, and 0.972, respectively if MPV≥13.04 fl was taken as the prediction cutoff value, whereas the sensitivity and specificity were found to be 74.1% and 92.5% when PCT≥4.65ng/ml was used as the prediction value. Conclusion of MPV with PCT examinations is promising for prediction of the outcomes of acute pancreatitis.

Key words: Procalcitionin, Mean platelet volume, Acute pancreatitis, Prognosis