• 中国科学论文统计源期刊
  • 中国科技核心期刊
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  • 日本科学技术振兴机构数据库(JST)
临床输血与检验

临床输血与检验 ›› 2017, Vol. 19 ›› Issue (4): 371-374.DOI: 10.3969/j.issn.1671-2587.2017.04.018

• 临床检验 • 上一篇    下一篇

脂蛋白（a）颗粒和质量浓度与冠状动脉粥样硬化斑块性质的关系*

黄小燕, 黄乐生, 王京   

  1. 519015 广东省中医院珠海医院（黄小燕,黄乐生）;
    首都医科大学北京朝阳医院（王京）
  • 收稿日期:2017-02-20 出版日期:2017-08-20 发布日期:2017-08-09
  • 作者简介:黄小燕（1974-）,女,副主任技师,学士,主要从事临床生物化学和免疫学检测工作,（Tel）18922358031。
  • 基金资助:
    *本课题受广东省珠海市科技计划项目（No; 20161027E030007）资助

Analysis of Relationship between Particle or Mass Concentration of Lipoprotein（a） and Character of Atherosclerotic Plaques

Huang Xiao-yan, Huang Le-sheng, Wang Jing   

  1. Department of Laboratory Medicine,Guangdong Hospital of Traditional Chinese Medicine 519015
  • Received:2017-02-20 Online:2017-08-20 Published:2017-08-09

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摘要： 目的 比较脂蛋白（a）颗粒和质量浓度与冠状动脉粥样硬化斑块性质的关系,分析脂蛋白（a）在冠状动脉粥样硬化斑块形成中的作用。方法 回顾分析了自2015年1月~2016年8月在某院行冠状动脉电脑断层造影（CTA）检查的91例患者病情资料,根据CTA结果将患者分为观察组和冠状动脉粥样硬化性心脏病（CAHD）组,比较两组患者血液脂蛋白（a）的颗粒和质量浓度。另根据患者斑块性质,将CAHD组患者分为软斑块组、混合斑块组和钙化斑块组,比较脂蛋白（a）在不同斑块性质分组中的浓度变化。同时比较脂蛋白（a）颗粒浓度和质量浓度的关系。结果 CAHD组患者脂蛋白（a）的颗粒浓度和质量浓度都显著高于对照组（t=3.4707,P=0.0008和t=3.1524,P=0.0022）。不同斑块性质分组中脂蛋白（a）的颗粒浓度和质量浓度的差异有统计学意义（F=55.175,P<0.0001和F=6.124,P=0.004）,其中钙化斑块组脂蛋白（a）的颗粒浓度和质量浓度最高（P<0.05）。脂蛋白（a）的颗粒浓度和质量浓度间存在一定相关性（r=0.5646,P<0.0001）。结论 冠状动脉粥样硬化性心脏病患者血清脂蛋白（a）的表达明显升高,且脂蛋白（a）浓度与斑块性质有关,可能在不同性质斑块的形成中发挥不同的作用。

关键词: 脂蛋白（a）颗粒浓度, 质量浓度, 冠状动脉粥样硬化, 斑块性质

Abstract: Objective To compare the particle or mass concentration of lipoprotein（a） and the character of atherosclerotic plaques and to analysis the effect of lipoprotein（a） on the formation of atherosclerotic plaques. Methods A retrospective study of total 91 patients who underwent computed tomography angiography （CTA） in our hospital from January 2015 to August 2016 were performed. Based on the result of CTA,those patients were divided into two groups,the control group and the coronary atherosclerotic heart disease （CAHD） group. The particle and mass concentration of lipoprotein（a） were compared between two groups. Additionally,according to the character of atherosclerotic plaques,patients in the CAHD group were further divided into three group,comprised of the soft plaque group,the mixed plaque group and the calcific plaque group. The particle and mass concentration of lipoprotein（a） in these three groups were also compared. The correlation between particle concentration and mass concentration of lipoprotein（a） was analyzed. Results The particle and mass concentration of lipoprotein（a） were significantly higher in the CAHD group compared to the control group （t=3.4707,P=0.0008 and t=3.1524,P=0.0022）. The obvious difference of particle and mass concentration of lipoprotein（a） was observed in three groups of different character of atherosclerotic plaques （F=55.175,P<0.0001 and F=6.124,P=0.004）. Among those three groups,patients in the calcific plaque group had the highest level of particle and mass concentration of lipoprotein（a） （P<0.05）. The correlation between the particle concentration and the mass concentration of lipoprotein（a） was seen （r=0.5646,P<0.0001）. Conclusion Elevated level of lipoprotein（a） could be seen in CAHD patients,and the level of lipoprotein（a） has relationship with the character of atherosclerotic plaques. Lipoprotein（a） could play different roles in the formation of different kind of atherosclerotic plaques.

Key words: Lipoprotein（a） particle concentration, Mass concentration, Coronary atherosclerosis, Character of atherosclerotic plaques

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