血清粘附分子SE-CAD、SE-SEL和sICAM-1 在肺癌诊断中的应用*

doi:10.3969/j.issn.1671-2587.2017.04.021

临床输血与检验 ›› 2017, Vol. 19 ›› Issue (4): 382-385.DOI: 10.3969/j.issn.1671-2587.2017.04.021

血清粘附分子SE-CAD、SE-SEL和sICAM-1 在肺癌诊断中的应用^*

武彩虹, 银广悦, 钱成荣, 田雪梅, 徐翠玲, 张维

065000 廊坊,中国石油天然气集团公司中心医院

收稿日期:2017-02-18 出版日期:2017-08-20 发布日期:2017-08-09
通讯作者: 银广悦,男,主任技师,主要从事实验室诊断方面工作,（Tel）0316–2075450（E-mail）rainbowhb@sohu.com。
作者简介:武彩虹（1979-）,女,内蒙古人,主管技师,硕士,主要从事肿瘤免疫方面工作,（Tel）13643161582。
基金资助:
*本课题受河北省廊坊市科技局项目（No.2014013022）资助

Serum Adhesion Molecules SE-Cadherin、SE-Selectin and sIntercellular Adhesion Molecule-1 as Lung Cancer Biomarkers

WU Cai-hong, YIN Guang-yue, QIAN Cheng-rong, et al

Department of Clinical Laboratory,China Petroleum Natural Gas Group Central Hospital,Langfang,Hebei 065000

Received:2017-02-18 Online:2017-08-20 Published:2017-08-09

摘要/Abstract

摘要： 目的探讨可溶性E-钙黏蛋白（soluble E-cadherin,SE-CAD）、可溶性E选择素（soluble E-selectin,SE-SEL）、可溶性细胞间粘附分子1（soluble Intercellular adhesion molecule-1,sICAM-1）在肺癌临床诊断中的价值。方法选取2011年6月~2014年12月在本院确诊的168例患者,均经组织学确诊为肺癌,其中小细胞肺癌（small cell lung cancer,SCLC）98例、非小细胞肺癌（non-small cell lung cancer,NSCLC）70例,肺部良性疾病患者和健康自愿者各50例。所有患者采集静脉血分离血清,采用抗SE-CAD、抗SE-SEL和抗sICAM-1的单克隆抗体试剂盒ELISA方法测定血清粘附分子。结果 SCLC和NSCLC患者血清SE-CAD、SE-SEL和sICAM-1水平显著高于健康组和良性疾病组（P﹤0.05）,而且肿瘤发生转移（III~IV期）的患者血清SE-CAD水平高于无转移（I~II期）的患者（P﹤0.05）,但SE-SEL与sICAM-1与是否发生转移没有相关性。结论 SE-CAD、SE-SEL和sICAM-1对肺癌临床诊断具有一定价值,而且SE-CAD可作为判断肿瘤是否扩散的一个有用指标,从而进行疗效观察和愈后评估。

关键词: 小细胞肺癌, 非小细胞肺癌, 可溶性E-钙黏蛋白, 可溶性E选择素, 可溶性细胞间粘附分子

Abstract: Objective In the present study,we investigated the role of soluble E-cadherin （SE-CAD）,soluble E-selectin （SE-SEL） and soluble intercellular adhesion molecule-1 （sICAM-1） as biomarkers in lung cancer. Methods 168 patients with recently diagnosed lung cancer,98 with small cell lung cancer（SCLC）,and 70 with non-small cell lung cancer （NSCLC）,50 cases of patients with benign pulmonary diseases as well as 50 healthy volunteers were enrolled. Blood samples were collected at the time of diagnosis and measurement of soluble adhesion molecules in the serum samples was performed by enzyme-linked immunoassay using monoclonal antibodies against E-cadherin,E-selectin,and ICAM-1. Results Serum levels of SE-CAD,SE-SEL,and sICAM-1 in both SCLC and NSCLC were significantly higher than the healthy subjects and the group with benign pulmonary diseases （P<0.05）. In addition,patients with SCLC or NSCLC with distant metastasis had a marked increase of SE-CAD（P<0.05）,but no such correlation with SE-SEL and sICAM-1 was found. Conclusions Our findings suggest that SE-CAD,SE-SEL,and sICAM-1 have an adjunctive diagnostic role in lung cancer. Furthermore,SE-CAD may also have a prognostic value and could be a useful biomarker in the prediction of lung cancer outcome.

Key words: SCLC, NSCLC, SE-CAD, SE-SEL, sICAM-1

中图分类号:

R734.2

武彩虹, 银广悦, 钱成荣, 田雪梅, 徐翠玲, 张维. 血清粘附分子SE-CAD、SE-SEL和sICAM-1 在肺癌诊断中的应用^*[J]. 临床输血与检验, 2017, 19(4): 382-385.

WU Cai-hong, YIN Guang-yue, QIAN Cheng-rong, et al. Serum Adhesion Molecules SE-Cadherin、SE-Selectin and sIntercellular Adhesion Molecule-1 as Lung Cancer Biomarkers[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2017, 19(4): 382-385.

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血清粘附分子SE-CAD、SE-SEL和sICAM-1 在肺癌诊断中的应用^*

Serum Adhesion Molecules SE-Cadherin、SE-Selectin and sIntercellular Adhesion Molecule-1 as Lung Cancer Biomarkers

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