关键词: 脑肿瘤, 胰岛素样生长因子-I, 胰岛素样生长因子结合蛋白-3, 脑垂体瘤

Abstract: Objective To investigate the value of detecting the expression serum levels of insulin-like growth factor-I （IGF-I） and insulin-like growth factor binding protein-3（IGFBP-3） in patients with brain tumor. Methods Serum levels of IGF-I and IGFPB-3 were detected by chemiluminescence in several patients with brain tumor,Of which 16 cases of meningioma,13 cases of glioma,32 cases of GH secreting pituitary adenoma,40 cases of non-GH secreting pituitary tumors and 30 healthy controls. Results The serum level of IGF-I and IGFPB-3 in group of meningiomas and GH secreting pituitary adenoma were higher than that in the healthy control group （P<0.05）; The serum level of IGF-I and IGFPB-3 in GH secreting pituitary tumors were higher than that in non-GH secreting pituitary adenoma; The serum level of IGF-I in GH secreting pituitary tumors preoperative were higher than that after surgery （P<0.05）. Conclusion （1） The serum level of IGF-I and IGFPB-3 increased in many patients with brain tumors,detecting their level can assist the diagnosis of certain brain tumors; （2） The serum level of IGF-I and IGFPB-3 was significantly different in secreted and non-secreting pituitary tumors,which can take differential diagnosis on different type of pituitary tumor; （3） The serum level of IGF-I and IGFPB-3 in GH secreting pituitary tumors preoperative were significantly higher than that after surgery,which can monitor the effect of surgery and observe patient recovery situation by detecting the speed and extent of IGF-I decline after surgery.

Key words: Brain tumors, Insulin-like growth factor-I, Insulin-like growth factor binding protein-3, Pituitary tumor