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临床输血与检验

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (1): 56-58.DOI: 10.3969/j.issn.1671-2587.2019.01.019

• 临床检验 • 上一篇    下一篇

总胆固醇及肌酐水平检测对急性心肌梗死患者PCI治疗预后的影响*

曾阳, 王玲   

  1. 615000 四川省西昌市人民医院检验科
  • 收稿日期:2018-09-11 出版日期:2019-02-20 发布日期:2019-01-28
  • 作者简介:曾阳（1979-）,女,四川西昌人,主管技师,本科,主要从事生化、免疫常规检验工作,（Tel）18181305622。
  • 基金资助:
    本课题受国家高技术研究院发展计划（863计划）子课题（No.2015AA021107)资助

Significance of Total Cholesterol and Creatinine Detection in PCI Prognosis of the Patients with Acute Myocardial Infarction

ZENG Yang   

  1. Department of Laboratory Diagnostics of Xichang Hospital,Xichang,Sichuan 615000
  • Received:2018-09-11 Online:2019-02-20 Published:2019-01-28

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摘要： 目的 探究总胆固醇及肌酐水平检测对急性心肌梗死患者经皮冠状动脉介入治疗（PCI）预后的影响。方法 选取2016年12月~2017年5月本院收治的确诊为急性心肌梗死并行PCI治疗的患者68例为观察对象,所有患者出院后随访6个月,按照随访中是否发生心脏不良事件分为预后良好组（n=41）与预后不良组（n=27）,比较两组患者治疗前后外周血总胆固醇及肌酐水平,并采用受试者工作特征曲线（ROC）分析其对治疗预后的评估价值。结果 预后不良组患者治疗前后总胆固醇及肌酐水平均明显高于预后良好组的（P<0.05）,pearson相关分析显示患者PCI治疗后心脏不良事件发生率与血总胆固醇及肌酐水平呈正相关（r=0.246,r=0.451,P<0.05）,ROC曲线分析显示总胆固醇联合肌酐水平检测对急性心梗患者行PCI治疗后出现预后不良的敏感度为81.48%,特异度为85.37%。结论 总胆固醇及肌酐水平与患者心血管受损程度相关,联合检测上述指标可作为预估患者预后情况的辅助手段之一。

关键词: 急性心肌梗死, 经皮冠状动脉介入治疗, 肌酐, 胆固醇

Abstract: Objective To investigate the significance of total cholesterol and creatinine in prognosis of percutaneous coronary intervention （PCI） in patients with acute myocardial infarction （AMI） Methods 68 cases of PCI with AMI in the hospital were collected in 2016-2017. All subjects were divided into two groups of favourable （n=41） and unfavourable prognosis （n=27） according to the occurrence of adverse cardiac events in the follow-up period. The levels of total cholesterol and creatinine were compared before and after treatments. The ROC curve was used to evaluate the prognostic value of the treatments. Results The levels of total cholesterol and creatinine in patients with unfavourable prognosis were significantly elevated compared to those of unfavourable prognosis （P<0.05）. Pearson correlation analysis showed that the incidence of cardiac adverse events following PCI treatments was positively correlated with total cholesterol and creatinine （r=0.246,r=0.451,P<0.05）. ROC curve analysis showed that the detection sensitivity of total cholesterol combined with creatinine in AMI patients after PCI treatments was 81.48%,and the specificity was 85.37%. Conclusion The levels of cholesterol and creatinine are related to the severity of cardiovascular damage,and the combined measurements of total cholesterol and creatinine is useful for prediction of the prognosis of PCI patients with acute myocardial infarction.

Key words: Acute myocardial infarction, Percutaneous coronary intervention, Creatinine, Cholesterol

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