• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (5): 485-487.DOI: 10.3969/j.issn.1671-2587.2019.05.011

• 血液检测 • 上一篇    下一篇

新喋呤作为潜在血液筛查标志物的意义探讨

杨扬   

  1. 300110 天津市血液中心
  • 收稿日期:2018-10-25 出版日期:2019-10-20 发布日期:2019-10-29
  • 作者简介:杨扬(1982-),女,天津人,副主任技师,硕士,主要从事固定献血者建设、血液检测等研究,(Tel)13820937656(E-mail)yang4430@sina.com。

The Significance of Neopterin Detection for Screening Blood Donors

YANG Yang   

  1. Tianjin Blood Centre,Tianjin,300110
  • Received:2018-10-25 Online:2019-10-20 Published:2019-10-29

摘要: 目的 检测正常和病毒感染标本的血清新喋呤浓度,探讨新喋呤用于无偿献血者筛查的意义。方法 随机选取无偿献血者血液病毒标志物(HBsAg、抗-HCV、抗-HIV和梅毒抗体)经ELISA法筛查结果为正常、单阳性和双阳性的血清标本各50例,检测新喋呤浓度。HBsAg、抗-HCV、抗-HIV、梅毒抗体均使用不同试剂盒进行双孔检测,单孔呈阳性反应标本为单阳,双孔同时呈阳性反应标本为双阳,均呈阴性反应标本为正常。新喋呤浓度采用ELISA法检测后进行浓度换算。结果 单阳、双阳组血清新喋呤浓度较正常组明显升高,组间比较差异均有统计学意义(P<0.01)。结论 血清新喋呤浓度在不同状态病毒感染标本中均明显增高,用于无偿献血者筛查具有一定的可行性。

关键词: 新喋呤浓度, 病毒感染, 献血者筛查

Abstract: Objective To analyze the significance of Neopterin detection for screening blood donors by tested the serum Neopterin levels in virus negative and positive serum samples.Methods The virus markers(HBsAg,anti-HCV,anti-HIV and syphilis) were screened using different ELISA kits for dual hole detection. According to the results,the serum samples were divided into normal,single-positive and double-positive groups(50 cases in each group randomly).Totally 150 samples were used to detect the Neopterin levels via ELISA kits.Results Compared with the normal group,the Neopterin levels in single-positive and double-positive groups were significantly elevated,meanwhile,the differences between groups also had statistical significance(P<0.01).ConclusionSerum Neopterin concentration was significantly increased in different condition of viral infection samples,which was feasible for screening blood donors.

Key words: Neopterin levels, Viral infection, Blood donors screening

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