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临床输血与检验

临床输血与检验 ›› 2021, Vol. 23 ›› Issue (1): 38-40.DOI: 10.3969/j.issn.1671-2587.2021.01.010

• 新生儿溶血病专题 • 上一篇    下一篇

抗-D抗体致新生儿溶血病的输血策略及其预后疗效评估分析

王文婷, 党盼玉, 张保萍, 胡兴斌, 安群星, 尹文   

  1. 710032 陕西西安,空军军医大学西京医院输血科
  • 收稿日期:2020-10-26 发布日期:2021-02-22
  • 通讯作者: 尹文,男,教授,博士生导师,主要从事输血医学的基础和临床研究,（E-mail）yinwen@fmmu.edu.cn。
  • 作者简介:王文婷（1988-）,女,陕西合阳人,主管技师,学士,主要从事临床输血和输血相关研究,（E-mail）wangwenting1106@163.com。

Transfusion Strategy and Prognosis of Hemolytic Disease of the Fetus and Newborn Caused by Anti-D Antibody

WANG Wen-ting, DANG Pan-yu, ZHANG Bao-ping, et al   

  1. Department of Blood Transfusion,Xijing Hospital,the Fouth Military Medical University,Xi'an 710032
  • Received:2020-10-26 Published:2021-02-22

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摘要： 目的 探讨由抗-D抗体致新生儿溶血病患者的输血策略及其预后疗效评估。方法 纳入2015年1月~2019年12月我院收治的抗-D抗体新生儿溶血病患者10例作为研究对象,均进行配合型输血治疗,观察治疗前后患者血常规指标变化、血液生化指标变化。结果 患者治疗前Hb、RBC、Hct值分别为（104.70±3.72）g/L、（3.01±0.14）×1012/L、0.33±0.01,治疗后分别为（136.60±2.40）g/L、（4.09±0.17）×1012/L、0.40±0.01,治疗后明显优于治疗前（P<0.05）;患者治疗前TBL、DBL 、IBL、LDH值分别为（294.09±26.91）μmol/L、（25.68±3.84）μmol/L、（268.41±24.16）μmol/L,（591.60±59.69）IU/L,治疗后分别为（164.86±25.4）μmol/L、（16.03±1.86) μmol/L、（143.41±24.3）μmol/L,（347.20±33.82）IU/L,治疗后明显优于治疗前（P<0.05）。结论 抗-D抗体新生儿溶血病患者输血首选ABO血型同患者血型一致的RhD阴性血液,其输血后临床效果显著,预后良好。

关键词: 抗-D抗体, 新生儿溶血病, 配合型输血, 输血治疗效果

Abstract: Objective To investigate the transfusion strategy and prognostic effectiveness of hemolytic disease of the fetus and newborn（HDFN）caused by anti-D antibody. Methods Ten patients diagnosed with HDFN due to anti-D antibody at our hospital between January 2015 and December 2019 were enrolled,all of whom were treated with compatible blood. Changes in blood routine indexes and blood biochemical indexes before and after treatment were observed. Results The values of Hb,RBC and Hct before treatment were（104.70±3.72）g/L,（3.01±0.14）×1012/L,（0.33±0.01）%,and these values after treatment were（136.60±2.40）g/L,（4.09±0.17）×1012/L,（0.40±0.01）%,respectively. The indexes after treatment was significantly better than those before treatment（P<0.05）. The values of TBL,DBL,IBL and LDH before treatment were（294.09±26.91）mol/L,（25.68±3.84）mol/L,（268.41±24.16）mol/L,（591.60±59.69）IU/L,and these values after treatment were（164.86±25.4）mol/L,（16.03±1.86）mol/L,（143.41±24.3）mol/L,（347.20±33.82）IU/L,respectively. The indexes after treatment was significantly better than those before treatment（P<0.05）. Conclusion When a transfusion is given,it is preferable for patients with HFDN to receive blood of the same ABO and RhD negative type,and its clinical effect after transfusion is good.

Key words: Anti-D antibody, Hemolytic disease of newborn, Compatible transfusion, Therapeutic effect of blood transfusion

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