红细胞Rh血型相容性输血临床意义与经济性分析*

doi:10.3969/j.issn.1671-2587.2023.06.012

临床输血与检验 ›› 2023, Vol. 25 ›› Issue (6): 783-788.DOI: 10.3969/j.issn.1671-2587.2023.06.012

红细胞Rh血型相容性输血临床意义与经济性分析^*

蓝燕飞, 钟明璐, 陈小洁, 杨秀华, 刘珍, 童欣欣, 黄慧瑛, 阳雪新, 刘昌杰, 苑召虎, 魏亚明

华南理工大学医学院第二附属医院输血科; 广州市第一人民医院输血科; 广东省精准输血研究中心,广东广州 510000

收稿日期:2023-11-13 出版日期:2023-12-20 发布日期:2024-01-15
通讯作者: 苑召虎,主要从事输血治疗相关研究,（E-mail）eyyuanzhaohu@scut.edu.cn。共同通信作者：魏亚明,主要从事输血治疗相关研究,（E-mail）eywym@scut.edu.cn。
作者简介:蓝燕飞,主要从事输血治疗研究,（E-mail）1410057731@qq.com。并列第一作者：钟明璐,主要从事输血治疗相关研究,（E-mail）drzhongml@163.com。
基金资助:
*本课题受广州市临床重大技术项目（No.2019ZD18）和广东省企联合面上项目（No.2021A1515220044）资助

Clinical Significance and Economic Analysis of Erythrocyte Rh Blood Group Compatible Transfusion

LAN Yanfei, ZHONG Minglu, CHEN Xiaojie, et al

Department of Blood Transfusion, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510000

Received:2023-11-13 Online:2023-12-20 Published:2024-01-15

摘要/Abstract

摘要： 目的分析我院开展RhD,C,c,E,e抗原相容性输血的临床意义与经济性,为以后全面推广和普及Rh血型相容性输血以及卫生行政部门决策提供科学依据。方法我们筛查并鉴定了Rh相容性输血组和对照组之间的意外抗体的产生情况。分析了Rh分型前后两年患者的住院时长和输血相关费用。结果献血者红细胞的Rh抗原表型与患者的Rh抗原表型匹配度可高达92.43%。住院患者的意外抗体阳性率为1.72%（186/10 786）,Rh血型系统抗体的检出率为43.30%,抗-Mi^a抗体的检出率为20.98%。接受Rh相容性输血的患者未产生新的Rh血型系统的抗体。Rh分型后,患者的次均住院时长和红细胞费用均有轻微降低。结论 Rh相容性输血可以显著减少新的意外抗体的产生。Rh相容性输血导致的输血相关检测费用的增长没有明显增加医疗费用。Rh相容性输血是值得推广和普及的。

关键词: Rh相容性输血, 意外抗体, 费用

Abstract: Objective To analyze the clinical significance and economic analysis of RhD, C, c, E, e antigen compatible blood transfusion in our hospital, and provide scientific basis for the comprehensive promotion and popularization of Rh compatible blood transfusion and the decision-making of health administrative departments in the future. Methods We screened and identified the production of unexpected antibodies between Rh compatible transfusion group and control group. The length of hospital stay (LOS) and the cost of transfusion-related testing were analyzed in the two years before and after Rh phenotyping. Results The Rh antigen compatibility between donors' red blood cells and patients was high enough to transfuse Rh matched red blood cells for 92.43% of patients. The total ratio of unexpected antibodies was 1.72% (186/10,786), the antibody frequency of Rh system was 43.30%, anti-Mi^a was 20.98%. There is no new development of Rh system antibodies after Rh compatible transfusion. After Rh phenotyping, the mean LOS and the cost of red blood cells were slightly decreased. Conclusion Rh compatible transfusion can significantly diminish new unexpected antibodies. The increased cost of transfusion-related testing due to Rh compatible transfusion did not significantly increase medical costs. Rh compatible blood transfusion is worth promoting and popularizing.

Key words: Rh compatible transfusion, Unexpected antibody, Cost

中图分类号:

R457

蓝燕飞, 钟明璐, 陈小洁, 杨秀华, 刘珍, 童欣欣, 黄慧瑛, 阳雪新, 刘昌杰, 苑召虎, 魏亚明. 红细胞Rh血型相容性输血临床意义与经济性分析^*[J]. 临床输血与检验, 2023, 25(6): 783-788.

LAN Yanfei, ZHONG Minglu, CHEN Xiaojie, et al. Clinical Significance and Economic Analysis of Erythrocyte Rh Blood Group Compatible Transfusion[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(6): 783-788.

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红细胞Rh血型相容性输血临床意义与经济性分析^*

Clinical Significance and Economic Analysis of Erythrocyte Rh Blood Group Compatible Transfusion

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