胎母输血综合征检测方法与相关疾病的研究进展*

doi:10.3969/j.issn.1671-2587.2024.03.021

临床输血与检验 ›› 2024, Vol. 26 ›› Issue (3): 426-432.DOI: 10.3969/j.issn.1671-2587.2024.03.021

• 综述 • 上一篇

胎母输血综合征检测方法与相关疾病的研究进展^*

王国美, 杨佶军, 刘铁梅

吉林大学中日联谊医院,吉林长春 130022

收稿日期:2023-12-24 出版日期:2024-06-20 发布日期:2024-06-24
通讯作者: 刘铁梅,主要从事临床输血方向,（E-mail）liutiemei777@163.com。
作者简介:王国美,主要从事临床检验诊断学方向,（E-mail）wanggm22@mails.jlu.edu.cn。
基金资助:
*吉林省科技厅项目（No.20230508069RC）资助

Advances in the Detection of Fetalmaternal Transfusion Syndrome and Related Disorders

WANG Guomei, YANG Jijun, LIU Tiemei

China-Japan Union Hospital of Jilin University, Changchun Jilin Province 130022

Received:2023-12-24 Online:2024-06-20 Published:2024-06-24

摘要/Abstract

摘要： 胎母输血综合征（fetomaternal hemorrhage,FMH）是指分娩前或分娩过程中,胎儿红细胞进入母体循环,母亲产生针对胎儿红细胞表面抗原的抗体,结合红细胞表面抗原使胎儿红细胞发生不同程度溶血的一系列反应。准确定量胎母出血的量对预防包括新生儿溶血病在内的新生儿出生缺陷至关重要。本文基于国内外最新相关文献,分析了FMH的新型和传统检测方法,阐明了各种检测方法的优势及不足之处,同时对FMH和各种围产期胎儿临床疾病的相关性作出了简要概述,为胎母输血综合征检测技术的标准规范化以及进一步预防诊治相关疾病提供依据。

关键词: 胎母输血综合征, 检测方法, 临床应用相关性

Abstract: Fetomaternal hemorrhage (FMH) is a series of reactions in which fetal red blood cells enter the maternal circulation before or during delivery, and the mother produces antibodies against fetal red blood cells, which in combination with red blood cell surface antigens cause fetal red blood cells to undergo varying degrees of hemolysis. Accurate quantification of fetalmaternal hemorrhage is crucial for the prevention of neonatal birth defects including neonatal hemolytic disease. Based on the latest relevant literature at home and abroad, this article analyzes the new and traditional detection methods for FMH, elucidates the advantages and shortcomings of various detection methods, and briefly outlines the correlation between FMH and various perinatal fetal clinical disorders, in order to provide a basis for standardization of testing techniques for fetalmaternal hemorrhage and further prevention and treatment of related diseases.

Key words: Foetomaternal haemorrhage, Detection methods, Clinical relevance

中图分类号:

R714.2

王国美, 杨佶军, 刘铁梅. 胎母输血综合征检测方法与相关疾病的研究进展^*[J]. 临床输血与检验, 2024, 26(3): 426-432.

WANG Guomei, YANG Jijun, LIU Tiemei. Advances in the Detection of Fetalmaternal Transfusion Syndrome and Related Disorders[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2024, 26(3): 426-432.

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胎母输血综合征检测方法与相关疾病的研究进展^*

Advances in the Detection of Fetalmaternal Transfusion Syndrome and Related Disorders

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