168例哌拉西林钠他唑巴坦钠诱导机体产生药物依赖性红细胞抗体分析

doi:10.3969/j.issn.1671-2587.2026.03.009

临床输血与检验 ›› 2026, Vol. 28 ›› Issue (3): 355-358.DOI: 10.3969/j.issn.1671-2587.2026.03.009

168例哌拉西林钠他唑巴坦钠诱导机体产生药物依赖性红细胞抗体分析

占冬青, 黄燕雪, 唐聪海

福建省漳州市医院输血科,福建漳州 363000

收稿日期:2025-09-02 出版日期:2026-06-20 发布日期:2026-07-07
通讯作者: 唐聪海,主要从事输血治疗、合理用血和输血信息化研究,（E-mail）23095721@qq.com。
作者简介:占冬青,主要从事输血医学研究,（E-mail）13063124918@163.com。

Analysis of Drug-dependent Red Blood Cell Antibodies Induced by Piperacillin-tazobactam in 168 Cases

ZHAN Dongqing, HUANG Yanxue, TANG Conghai

Department of Blood Transfusion, Zhangzhou Hospital, Fujian Province, Zhangzhou 363000

Received:2025-09-02 Online:2026-06-20 Published:2026-07-07

摘要/Abstract

摘要： 目的研究使用哌拉西林钠他唑巴坦钠患者体内产生药物依赖性红细胞抗体的几率、相关影响因素以及对患者的影响。方法选择2020年11月—2023年9月,新入院首次使用哌拉西林钠他唑巴坦钠治疗的患者共168例,分别对用药前和用药后第7天的血液样本进行直接抗人球蛋白试验（DAT）、不规则抗体筛查和哌拉西林抗体检测,并分析患者血细胞中淋巴细胞比值。结果用药后第7天,DAT阳性28例（16.7%）;哌拉西林抗体阳性15例（8.9%）,其中DAT阳性3例（20%）,抗体效价≥2+有7例（46.7%）。哌拉西林抗体阳性者淋巴细胞比值（42.3%±27.3%）明显高于阴性者（26.4%±19.7%）,差异存在统计学意义（P<0.05）。结论使用哌拉西林钠他唑巴坦钠后产生药物依赖性红细胞抗体的几率为8.9%,哌拉西林抗体的产生与患者淋巴细胞比值存在明显的相关性。

关键词: 药物依赖性抗体, 哌拉西林钠他唑巴坦钠, 哌拉西林抗体, 药物诱导的免疫性溶血性贫血, 药物诱导的免疫性血小板减少症

Abstract: Objective To study the probability of drug-dependent red blood cell antibodies produced in patients using piperacillin-tazobactam , related influencing factors and the impact on patients. Methods A total of 168 newly admitted patients who were treated with piperacillin-tazobactam for the first time from June 2020 to September 2023 were selected. Direct antiglobulin test (DAT), irregular antibody screening and piperacillin antibody detection were performed to test blood samples from patients treated with piperacillin-tazobactam after 7th day or before, and the ratio of lymphocytes in blood cells was analyzed. Results On the 7th day after medication, DAT was positive in 28 cases (16.7%) and piperacillin antibody was positive in 15 cases (8.9%). Among them, 3 cases (20%) were DAT positive, and 7 cases (46.7%) had antibody titer≥2+. The lymphocyte ratio of piperacillin antibody positive patients (42.3%±27.3%) was significantly higher than that of piperacillin antibody negative patients (26.4%±19.7%), and the difference was statistically significant (P<0.05). Conclusion The incidence of drug-dependent red blood cell antibody was 8.9% after using piperacillin-tazobactam. There is a significant correlation between the production of piperacillin antibody and the lymphocyte ratio of patients.

Key words: Drug-dependent antibody, Piperacillin-tazobactam, Piperacillin antibody, Drug-induced immune haemolytic anaemia, Drug-induced immune thrombocytopenia

中图分类号:

R392.11

占冬青, 黄燕雪, 唐聪海. 168例哌拉西林钠他唑巴坦钠诱导机体产生药物依赖性红细胞抗体分析[J]. 临床输血与检验, 2026, 28(3): 355-358.

ZHAN Dongqing, HUANG Yanxue, TANG Conghai. Analysis of Drug-dependent Red Blood Cell Antibodies Induced by Piperacillin-tazobactam in 168 Cases[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2026, 28(3): 355-358.

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168例哌拉西林钠他唑巴坦钠诱导机体产生药物依赖性红细胞抗体分析

Analysis of Drug-dependent Red Blood Cell Antibodies Induced by Piperacillin-tazobactam in 168 Cases

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