自体单采富血小板血浆与玻璃酸钠治疗膝骨关节炎短期疗效的对比分析*

doi:10.3969/j.issn.1671-2587.2025.04.004

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (4): 456-461.DOI: 10.3969/j.issn.1671-2587.2025.04.004

自体单采富血小板血浆与玻璃酸钠治疗膝骨关节炎短期疗效的对比分析^*

张新萍^1,2, 马红霞¹, 王皓¹, 黄象艳¹

¹解放军联勤保障部队第九六〇医院输血医学科（解放军济南血液中心）,山东济南 250031;
²山东中医药大学第二临床医学院,山东济南 250031

收稿日期:2024-11-28 发布日期:2025-08-22
通讯作者: 黄象艳,主要从事输血检验和临床输血相关研究,（E-mail）xiangyan73@aliyun.com。
作者简介:张新萍,主要从事临床输血及富血小板血浆治疗性单采相关研究,（E-mail）15269166819@163.com。
基金资助:
*本课题受山东省济南市临床医学科技创新计划项目（No.202225073）资助

Comparative Analysis of Short-term Efficacy of Autologous Apheresis Platelet-rich Plasma and Hyaluronic Acid in the Treatment of Knee Osteoarthritis

ZHANG Xinping^1,2, MA Hongxia¹, WANG Hao¹, HUANG Xiangyan¹

¹Department of Transfusion Medicine, The 960th Hospital of the PLA Joint Logistics Support Force (Jinan Blood Center of the PLA), Shandong Jinan 250031;
²The Second School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Shandong Jinan 250031

Received:2024-11-28 Published:2025-08-22

摘要/Abstract

摘要： 目的分析比较自体单采富血小板血浆（platelet-rich plasma, PRP）和玻璃酸钠（hyaluronic acid, HA）治疗膝骨关节炎（knee osteoarthritis, KOA）的疗效,为自体单采PRP应用于KOA治疗提供科学依据。方法收集2022年1月—2023年6月在我院就诊并接受相关治疗和短期随访的60例KOA患者作回顾性分析,根据治疗方案不同分为PRP治疗组及HA治疗组,比较两组患者治疗前后视觉模拟量表（VAS）评分、西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评分以及膝关节功能Lysholm评分,并评定两组治疗1个月、治疗3个月的临床疗效。结果两组患者在治疗后1个月、3个月,VAS疼痛评分和WOMAC评分均较治疗前降低（P<0.05）、Lysholm评分较治疗前升高（P<0.05）,治疗后3个月相比治疗后1个月变化幅度更为明显（P<0.05）,且PRP治疗组评分变化较HA治疗组尤为显著（P<0.05）。结论在KOA患者短期疼痛缓解和功能改善方面,自体单采PRP治疗优于HA。

关键词: 膝骨关节炎, 自体单采富血小板血浆, 玻璃酸钠, 功能评分

Abstract: Objective To investigate the therapeutic effects of intra-articular injection of autologous apheresis platelet-rich plasma (PRP) and hyaluronic acid (HA) in the kenn of people with knee osteoarthritis (KOA). Methods From January 2022 to June 2023, 60 patients with KOA were randomly divided into two groups of intra-articular HA and PRP. The patients of the two groups were followed up for three months and different outcomes were recorded. The visual analog scale (VAS) scores, McMaster index (WOMAC) and Lysholm scores of knee function evaluated all patients at rest and during movements. Measurements were taken at the beginning, the first month treatmen and the third month of treatment. Results In both groups of patients, at 1 month and 3 months after treatment, the VAS pain score and WOMAC score were lower than the baseline value (P<0.05), while the Lysholm score was higher than the baseline value (P<0.05). The change at three months of treatment was more significant than that at one month of treatment (P<0.05). Moreover, the change in scores in PRP group were more significant than those in HA group (P<0.05). Conclusion In terms of short-term pain relief and functional improvement in patients with KOA, autologous apheresis PRP treatment is superior to HA.

Key words: Knee osteoarthritis, Autologous apheresis platelet-rich plasma, Hyaluronic acid, Functionality scoring

中图分类号:

R684.3
R457

张新萍, 马红霞, 王皓, 黄象艳. 自体单采富血小板血浆与玻璃酸钠治疗膝骨关节炎短期疗效的对比分析^*[J]. 临床输血与检验, 2025, 27(4): 456-461.

ZHANG Xinping, MA Hongxia, WANG Hao, HUANG Xiangyan. Comparative Analysis of Short-term Efficacy of Autologous Apheresis Platelet-rich Plasma and Hyaluronic Acid in the Treatment of Knee Osteoarthritis[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(4): 456-461.

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自体单采富血小板血浆与玻璃酸钠治疗膝骨关节炎短期疗效的对比分析^*

Comparative Analysis of Short-term Efficacy of Autologous Apheresis Platelet-rich Plasma and Hyaluronic Acid in the Treatment of Knee Osteoarthritis

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