肺结核合并贫血研究新进展*

doi:10.3969/j.issn.1671-2587.2025.06.021

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (6): 876-881.DOI: 10.3969/j.issn.1671-2587.2025.06.021

肺结核合并贫血研究新进展^*

齐畅^1,2, 蒋波笛², 孟祥红²

¹佳木斯大学基础医学院,黑龙江佳木斯 154007;
²解放军总医院第八医学中心输血医学科,北京 100091

收稿日期:2025-01-23 出版日期:2025-12-20 发布日期:2025-12-24
通讯作者: 孟祥红,主要从事临床输血与免疫研究,E-mail：xh5562@sina.com。
作者简介:齐畅,主要从事病原生物学研究,E-mail：1817592916@qq.com。
基金资助:
^*本课题受国家卫健委科技专项课题（No.2021KYSHX02302）资助

Recent Progress in Anemia in Patient with Pulmonary Tuberculosis

QI Chang^1,2, JIANG Bodi², MENG Xianghong²

¹Medical College of Basic Medicine, Jiamusi University, Jiamusi, Heilongjiang 154007;
²Department of Blood Transfusion Medicine, 8th Medical Center of PLA General Hospital, Beijing 100091

Received:2025-01-23 Online:2025-12-20 Published:2025-12-24

摘要/Abstract

摘要： 贫血是肺结核常见的并发症之一,其流行病学特征呈现显著的地域差异和人口差异。结核分枝杆菌通过影响宿主免疫系统功能、机体铁代谢水平和慢性炎症特性等原因造成肺结核患者贫血。贫血与肺结核的发生、发展密切相关,是肺结核进展和死亡的独立危险因素。临床应将抗结核治疗与纠正贫血措施紧密结合,深入探究其发病机制和相关危险因素,寻找有效干预措施,为肺结核患者的精准治疗提供理论依据。

关键词: 肺结核, 贫血, 结核分枝杆菌, 免疫紊乱, 铁调素, 微量元素, 铁代谢

Abstract: Anemia is a prevalent complication of pulmonary tuberculosis, exhibiting marked regional and demographic variations in its epidemiological characteristics. Mycobacterium tuberculosis induces anemia in pulmonary tuberculosis patients by impairing host immune function, altering systemic iron metabolism, and exacerbating chronic inflammatory responses. Anemia is intricately linked to the onset and progression of pulmonary tuberculosis and serves as an independent risk factor for disease deterioration and mortality. Clinically, anti-tuberculosis therapy should be integrated with strategies to address anemia. Furthermore, a deeper understanding of the pathogenesis and associated risk factors is warranted to identify effective interventions to provide a theoretical foundation for the precise management of pulmonary tuberculosis patients.

Key words: Pulmonary tuberculosis, Anemia, Mycobacterium tuberculosis, Immune dysfunction, Hepcidin, Trace elements, Iron metabolism

中图分类号:

R521R556

齐畅, 蒋波笛, 孟祥红. 肺结核合并贫血研究新进展^*[J]. 临床输血与检验, 2025, 27(6): 876-881.

QI Chang, JIANG Bodi, MENG Xianghong. Recent Progress in Anemia in Patient with Pulmonary Tuberculosis[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(6): 876-881.

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肺结核合并贫血研究新进展^*

Recent Progress in Anemia in Patient with Pulmonary Tuberculosis

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