PRP治疗膝骨关节炎的临床应用研究进展

doi:10.3969/j.issn.1671-2587.2020.06.024

临床输血与检验 ›› 2020, Vol. 22 ›› Issue (6): 659-663.DOI: 10.3969/j.issn.1671-2587.2020.06.024

PRP治疗膝骨关节炎的临床应用研究进展

王瑞含, 范金波, 周国均, 王飞, 刘久波

442000 湖北十堰市太和医院输血科

收稿日期:2019-07-26 出版日期:2020-12-20 发布日期:2021-01-18
通讯作者: 刘久波,男,主任医师,教授,主要从事临床输血、微循环学研究,(Tel)0719-8801132(E-mail)ljb169168@sina.com。
作者简介:王瑞含(1994-),女,山东菏泽人,硕士研究生,主要从事临床检验诊断学研究,(Tel)15871110108(E-mail)952017575@qq.com。

Received:2019-07-26 Online:2020-12-20 Published:2021-01-18

摘要/Abstract

摘要： 膝骨关节炎作为一种膝关节常见疾病,近年来患病率逐年增高。富血小板血浆是一种含有高浓度血小板的血液制品,这种血液制品被激活后可释放包含多种生长因子在内的生物活性物质,进而具有促进创面愈合等功能。近年来随着研究的深入及其在临床中的广泛应用,大量研究证明富血小板血浆可用于治疗膝骨关节炎、促进膝关节软骨再生、改善患者临床症状,特别适用于早期骨关节炎患者。尽管目前仍存在其制备方法需标准化、研究结果存在一定的偏倚等问题,尚需大样本试验及标准化方法进行论证。但结合各方面研究文献来看,富血小板血浆仍存在一定的应用前景,在治疗骨关节疾病、肌腱损伤、难愈创面等其他疾病方面具有广泛用途。

中图分类号:

R684.3

王瑞含, 范金波, 周国均, 王飞, 刘久波. PRP治疗膝骨关节炎的临床应用研究进展[J]. 临床输血与检验, 2020, 22(6): 659-663.

参考文献

[1] PATERSON K L,HUNTER D J,METCALF B R,et al.Efficacy of intra-articular injections of platelet-rich plasma as a symptom- and disease-modifying treatment for knee osteoarthritis - the RESTORE trial protocol[J].BMC Musculoskelet Disord,2018,19:272.
[2] MCALINDON T E,LAVALLEY M P,HARVEY W F,et al.Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis[J].JAMA,2017,317(19):1967.
[3] SÁNCHEZ M,ANITUA E,DELGADO D,et al.A new strategy to tackle severe knee osteoarthritis:Combination of intra-articular and intraosseous injections of Platelet Rich Plasma[J].Expert Opin Biol Ther,2016,16(5):627-643.
[4] LAPRADE R F,GEESLIN A G,MURRAY I R,et al.Biologic treatments for sports injuries II think tank—current concepts,future research,and barriers to advancement,part 1[J].Am J Sports Med,2016,44(12):3270-3283.
[5] RUAN S Q,DENG J,YAN L,et al.Evaluation of the effects of the combination of BMP-2-modified BMSCs and PRP on cartilage defects[J].Exp Ther Med,2018,16(6):4569-4577.
[6] SICLARI A,MASCARO G,KAPS C,et al.A 5-year follow-up after cartilage repair in the knee using a platelet-rich plasma-immersed polymer-based implant[J].Open Orthop J,2014,8(1):346-354.
[7] BUENDÍA-LÓPEZ D,MEDINA-QUIRÓS M,FERNÁNDEZ-VILLACAÑAS MARÍN M Á.Clinical and radiographic comparison of a single LP-PRP injection,a single hyaluronic acid injection and daily NSAID administration with a 52-week follow-up:a randomized controlled trial[J].J Orthop Traumatol,2018,19:3.
[8] FILARDO G,DI MATTEO B,DI MARTINO A,et al.Platelet-rich plasma intra-articular knee injections show No superiority versus viscosupplementation:a randomized controlled trial[J].Am J Sports Med,2015,43(7):1575-1582.
[9] SHEN L X,YUAN T,CHEN S B,et al.The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis:systematic review and meta-analysis of randomized controlled trials[J].J Orthop Surg Res,2017,12:16.
[10] KON E,MANDELBAUM B,BUDA R,et al.Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology:from early degeneration to osteoarthritis[J].Arthrosc:J Arthrosc Relat Surg,2011,27(11):1490-1501.
[11] USLU GÜVENDI E,AKIN A,GÜVENDI G,et al.Comparison of efficiency between corticosteroid and platelet rich plasma injection therapies in patients with knee osteoarthritis[J].Arch Rheumatol,2018,33(3):273-281.
[12] PATEL S,DHILLON M S,AGGARWAL S,et al.Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis[J].Am J Sports Med,2013,41(2):356-364.
[13] GÖRMELI G,GÖRMELI C A,ATAOGLU B,et al.Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis:a randomized,double-blind,placebo-controlled trial[J].Knee Surg Sports Traumatol Arthrosc,2017,25(3):958-965.
[14] MONTAÑEZ-HEREDIA E,IRÍZAR S,HUERTAS P,et al.Intra-articular injections of platelet-rich plasma versus hyaluronic acid in the treatment of osteoarthritic knee pain:a randomized clinical trial in the context of the Spanish national health care system[J].Int J Mol Sci,2016,17(7):1064.
[15] YU W X,XU P,HUANG G L,et al.Clinical therapy of hyaluronic acid combined with platelet-rich plasma for the treatment of knee osteoarthritis[J].Exp Ther Med,2018,16(3):2119-2125.
[16] CHOU L W,CHEN S H,KUAN T S,et al.Clinical effectiveness in severe knee osteoarthritis after intra-articular platelet-rich plasma in association with hyaluronic acid injection:three case reports[J].Clin Interv Aging,2016,11:1213-1219.
[17] 郭燕庆,于洪波,孟勇,等.应用富血小板血浆混合透明质酸钠治疗膝骨关节炎[J].中华关节外科杂志(电子版),2018,12(6):107-110.
[18] RUSSO F,D’ESTE M,VADALÀG,et al.Platelet rich plasma and hyaluronic acid blend for the treatment of osteoarthritis:rheological and biological evaluation[J].PLoS One,2016,11(6):e0157048.
[19] CAMPBELL T M,CHURCHMAN S M,GOMEZ A,et al.Mesenchymal stem cell alterations in bone marrow lesions in patients with hip osteoarthritis[J].Arthritis Rheumatol,2016,68(7):1648-1659.
[20] BASTOS R,MATHIAS M,ANDRADE R,et al.Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis:a controlled,double-blind clinical trial[J].Knee Surg Sports Traumatol Arthrosc,2020,28(6):1989-1999.
[21] LAMO-ESPINOSA J M,BLANCO J F,SÁNCHEZ M,et al.Phase II multicenter randomized controlled clinical trial on the efficacy of intra-articular injection of autologous bone marrow mesenchymal stem cells with platelet rich plasma for the treatment of knee osteoarthritis[J].J Transl Med,2020,18:356.
[22] RAHIMZADEH P,IMANI F,FAIZ S H R,et al.Adding intra-articular growth hormone to platelet rich plasma under ultrasound guidance in knee osteoarthritis:a comparative double-blind clinical trial[J].Anesth Pain Med,2016,6(6):e41719.
[23] KANCHANATAWAN W,ARIRACHAKARAN A,CHAIJENKIJ K,et al.Short-term outcomes of platelet-rich plasma injection for treatment of osteoarthritis of the knee[J].Knee Surg Sports Traumatol Arthrosc,2016,24(5):1665-1677.
[24] RIBOH J C,SALTZMAN B M,YANKE A B,et al.Effect of leukocyte concentration on the efficacy of platelet-rich plasma in the treatment of knee osteoarthritis[J].Am J Sports Med,2016,44(3):792-800.
[25] 宣力,田举,宣敏,等.二次离心法制备富血小板血浆中血小板相关参数的分析[J].华南国防医学杂志,2017,31(8):514-517.
[26] RUGHETTI A,GIUSTI I,D'ASCENZO S,et al.Platelet gel-released supernatant modulates the angiogenic capability of human endothelial cells[J].Blood Transfus,2008,6(1):12-17.
[27] FLEMING B C,PROFFEN B L,VAVKEN P,et al.Increased platelet concentration does not improve functional graft healing in bio-enhanced ACL reconstruction[J].Knee Surg Sports Traumatol Arthrosc,2015,23(4):1161-1170.
[28] 许育兵,刘广亚,朱展鸿,等.不同血小板浓度富血小板血浆对动物软骨细胞增殖的影响及其治疗膝骨关节炎的临床效果观察[J].中国输血杂志,2018,31(6):583-587.
[29] DHILLON M S,PATEL S,BANSAL T.Improvising PRP for use in osteoarthritis knee- upcoming trends and futuristic view[J].J Clin Orthop Trauma,2019,10(1):32-35.
[30] LE A D K,ENWEZE L,DEBAUN M R,et al.Current clinical recommendations for use of platelet-rich plasma[J].Curr Rev Musculoskelet Med,2018,11(4):624-634.

PRP治疗膝骨关节炎的临床应用研究进展

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 2

编辑推荐

Metrics

本文评价

关于本刊

作者中心

在线期刊

访问统计

联系我们

[1]	林放, 周谋, 单桂秋, 李艳辉, 李文丹. 不同来源复水液对冻干PRP活化和释放生长因子影响的比较^*[J]. 临床输血与检验, 2021, 23(2): 142-145.
[2]	王淑君, 赵广超, 栾建凤, 朱培元. 不同规格全血制备富血小板血浆的最佳离心条件研究^*[J]. 临床输血与检验, 2017, 19(2): 119-122.