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临床输血与检验

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (1): 70-75.DOI: 10.3969/j.issn.1671-2587.2025.01.010

• 临床输血 • 上一篇    下一篇

湖南省ABO血型分布及其与恶性肿瘤的相关性分析*

李国才1, 桂嵘1, 黄雪原1, 屈琳2, 周雄辉1, 刘凤霞1   

  1. 1中南大学湘雅三医院输血科;
    2中南大学湘雅三医院检验科,湖南长沙 410013
  • 收稿日期:2024-08-29 发布日期:2025-02-25
  • 通讯作者: 刘凤霞,主要从事疑难血型血清学和基因方面研究,（E-mail）xy3liufengxia@csu.edu.cn。
  • 作者简介:李国才,主要从事疑难血型血清学研究,（E-mail）549924685@qq.com。
  • 基金资助:
    *本课题受湖南省自然科学基金面上项目（No.2024JJ5535）资助

The Distribution of ABO Blood Type and Its Correlation with Malignant Tumors in Hunan Province

LI Guocai1, GUI Rong1, HUANG Xueyuan1, QU Lin2, ZHOU Xionghui1, LIU Fengxia1   

  1. 1Department of Blood Transfusion, The Third Xiangya Hospital of Central South University, Changsha 410013;
    2Department of Laboratory Medicine, The Third Xiangya Hospital of Central South University 410013
  • Received:2024-08-29 Published:2025-02-25

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摘要： 目的 探讨湖南省ABO血型的分布以及ABO血型与恶性肿瘤的相关性。以期积累本地区血型分布数据,并揭示ABO血型与恶性肿瘤的潜在关联,为辅助疾病诊断以及血液库存管理提供依据。方法 收集2016─2023年于中南大学湘雅三医院就诊的具有ABO血型信息的患者及健康体检者的临床资料。研究采用描述性统计分析ABO血型在湖南省的分布情况。卡方检验（Chi-square test,χ2）比较恶性肿瘤患者与健康组ABO血型分布是否具有差异。Logistic回归分析计算不同ABO血型人群患某种恶性肿瘤的比值比（Odds Ratio,OR）。结果 湖南省的ABO血型分布结果为：O型（35.02%）>A型（34.45%）>B型（22.42%）>AB型（8.10%）。胃癌、结直肠癌、乳腺癌和宫颈癌患者ABO血型分布均为A型>O型>B型>AB型,白血病、淋巴瘤患者ABO血型分布则为O型>A型>B型>AB型,经χ2检验,与健康组相比差异具统计学意义（P<0.05）。Logistic回归分析结果显示,在湖南省,A型和O型人群患结直肠癌、乳腺癌和宫颈癌的OR显著高于AB型人群;A型人群患胃癌的OR显著高于AB型人群;O型人群患白血病的OR显著高于AB型人群;O型和B型人群患淋巴瘤的OR显著高于AB型人群（P<0.05）。结论 湖南省ABO血型分布为O型>A型>B型>AB型,并且在结直肠癌、宫颈癌和乳腺癌患者中,AB型是保护因素;在胃癌和宫颈癌患者中,B型是保护因素;在白血病和淋巴瘤患者中,A型、B型和AB型是保护因素。

关键词: ABO血型, 恶性肿瘤, 湖南省血型分布

Abstract: Objective To discuss the distribution of ABO blood type and the correlation between ABO blood type and malignant tumors in Hunan Province. This is to accumulate blood type distribution data and reveal the potential correlation between ABO blood type and malignant tumors to provide a basis for auxiliary disease diagnosis and blood inventory management. Methods The clinical data of patients with ABO blood type and healthy physical examination subjects in the Third Xiangya Hospital of Central South University from 2016 to 2023 were collected. Descriptive statistics were used to analyze the distribution of ABO blood type. The chi-square (χ2) test was used to compare the distribution of ABO blood types between patients with malignant tumors and healthy groups. Logistic regression analysis was used to calculate the odds ratio (OR) of ABO blood type in tumor groups. Results The ABO blood type distribution In Hunan Province was type O (35.02%)>type A (34.45%)>type B (22.42%)>type AB (8.10%). The ABO blood type distribution in patients with gastric cancer, colorectal cancer, breast cancer and cervical cancer was A>O>B>AB. The ABO blood type distribution in patients with leukemia and lymphoma was O>A>B>AB. The difference was statistically significant compared with the healthy group by χ2 test (P<0.05). Logistic regression analysis showed that in Hunan Province, the OR of colorectal cancer, breast cancer and cervical cancer in people with type A and O was significantly higher than that in people with type AB; the OR of gastric cancer in people with type A was significantly higher than that in people with group AB; the OR of leukemia in people with type O was significantly higher than that in people with type AB; the OR of lymphoma in people with type O and type B was significantly higher than that in people with type AB (P<0.05). Conclusion The ABO blood type distribution in Hunan Province was O>A>B>AB. Type AB is a protective factor in patients with colorectal cancer, cervical cancer and breast cancer; Type B is a protective factor in patients with gastric cancer and cervical cancer; Type A, B, and AB are protective factors in patients with leukemia and lymphoma.

Key words: ABO blood type, Malignant tumor, Blood type distribution in Hunan

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