Sema7a蛋白作用机制研究进展*

doi:10.3969/j.issn.1671-2587.2025.02.014

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (2): 234-246.DOI: 10.3969/j.issn.1671-2587.2025.02.014

Sema7a蛋白作用机制研究进展^*

赖冬娣^1,2,3, 钟明璐^1,2,3, 董涵^1,2, 彭伟康^1,2,3, 魏亚明^1,2,3, 苑召虎^1,2,3

¹广州市第一人民医院;
²广东省精准输血技术工程研究中心;
³广州医科大学输血与血液病研究所,广东广州 510180

收稿日期:2024-12-23 出版日期:2025-04-20 发布日期:2025-04-17
通讯作者: 苑召虎,主要从事输血免疫学研究,（E-mail）eyyuanzhaohu@scut.edu.cn。共同通信作者：魏亚明,主要从事输血治疗相关研究,（E-mail）eywym@scut.edu.cn。
作者简介:赖冬娣,主要从事输血治疗和输血医学免疫学研究,（E-mail）1337151807@qq.com。
基金资助:
*本课题受广东省自然科学基金省企联合项目（No. 2022A1515220019、No. 2021A1515220044）资助

New Progress on the Molecular Mechanism of Sema7a Protein

LAI Dongdi^1,2,3, ZHONG Minglu^1,2,3, DONG Han^1,2, PENG Weikang^1,2,3, WEI Yaming^1,2,3, YUAN Zhaohu^1,2,3

¹Department of Blood Transfusion, Guangzhou First Peoples Hospital, Guangzhou, 510180;
²Guangdong Engineering Research Centre of Precise Transfusion, Guangzhou, 510180;
³Research institute of Blood Transfusion and Hematology, Guangzhou Medical University, 510180

Received:2024-12-23 Online:2025-04-20 Published:2025-04-17

摘要/Abstract

摘要： 信号素家族成员Sema7a,也称为CDw108、JMH抗原,是一种糖基磷脂酰肌醇（glycosylphosphatidylinositol, GPI）锚定的糖蛋白,广泛表达在全身多种组织细胞膜上。Sema7a蛋白可以受酶、血液应切力、缺氧等多种物理化学因素影响,从细胞膜上裂解下来,其中来源于红细胞膜表面的Sema7a蛋白是体内游离Sema7a的主要来源。Sema7a蛋白与两种已知的受体——整合素和丛蛋白C1（Plexin C1）结合或以游离方式参与全身多种生物活动过程,在细胞分化、神经信号转导、免疫应答、炎症调节及肿瘤进展等方面具有重要作用。本文根据系统疾病分类,对Sema7a蛋白参与不同疾病发生、发展的机制进行了叙述和总结。

关键词: Sema7a, JMH抗原, 整合素, 丛蛋白C1

Abstract: Sema7a protein, a member of the semaphorin protein family, also known as CDw108 or JMH antigen, is a blood group antigen on the surface of erythrocyte membrane. It's a glycosylphosphatidylinositol (GPI)-anchored glycoprotein widely expressed on the cell membranes of various tissues throughout the body. The Sema7a protein can be cleaved from cell membrane by various physical and chemical factors, such as enzyme, blood shear force and hypoxia. The Sema7a protein on the surface of erythrocyte membrane is the main source of free Sema7a in vivo. The Sema7a protein can bind to two known receptors, integrin or PlexinC1 (PlexinC1), or in a free form to participate in various biological activities throughout the body, and plays an important role in cell differentiation, nerve signal transduction, immune response, inflammation regulation, and tumor progression. This review summarizes the mechanisms of Sema7a protein involvement in the occurrence and development of different diseases based on the classification of systemic disease.

Key words: Sema7a, JMH antigen, Integrin, Plexin C1

中图分类号:

Q516

赖冬娣, 钟明璐, 董涵, 彭伟康, 魏亚明, 苑召虎. Sema7a蛋白作用机制研究进展^*[J]. 临床输血与检验, 2025, 27(2): 234-246.

LAI Dongdi, ZHONG Minglu, DONG Han, PENG Weikang, WEI Yaming, YUAN Zhaohu. New Progress on the Molecular Mechanism of Sema7a Protein[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(2): 234-246.

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Sema7a蛋白作用机制研究进展^*

New Progress on the Molecular Mechanism of Sema7a Protein

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