血浆拓展性应用及相关成分研究进展*

doi:10.3969/j.issn.1671-2587.2025.02.018

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (2): 267-273.DOI: 10.3969/j.issn.1671-2587.2025.02.018

血浆拓展性应用及相关成分研究进展^*

李津杞¹, 钱宝华¹, 许硕贵², 顾海慧¹

¹海军军医大学第一附属医院输血科,上海 200433;
²海军军医大学第一附属医院创伤骨科,上海 200433

收稿日期:2024-12-04 出版日期:2025-04-20 发布日期:2025-04-17
通讯作者: 顾海慧,主要从事细胞治疗与干细胞来源血小板方面研究,（E-mail）haihuigu@126.com。
作者简介:李津杞,主要从事溶贫实验室和输血质控管理研究工作,（E-mail）ljq_421@163.com。
基金资助:
*本课题受国家自然科学基金面上项目（No.81970165）资助

Research Progress on Plasma Expansion Applications and Related Components

LI Jinqi¹, QIAN Baohua¹, XU Shuogui², GU Haihui¹

The First Affiliated Hospital of Naval Medical University, Shanghai 200433

Received:2024-12-04 Online:2025-04-20 Published:2025-04-17

摘要/Abstract

摘要： 血浆是临床输血的常用成分,主要适应症是补充凝血因子,预防或治疗凝血因子缺乏引起的出血或出血倾向。血浆置换和康复期血浆治疗已经扩展了血浆输注的临床应用,研究发现血浆输注还可缓解皮肤病,促进角膜再生等。动物实验发现年轻血浆可以通过恢复自噬,抑制凋亡,减少氧化应激和抗炎等途径抗衰老和缓解衰老相关疾病的临床表现。本文总结已发表的除康复期血浆治疗以外的血浆拓展性应用及相关成分动物实验与临床研究的进展,探讨血浆拓展性应用及可能分子作用机制,为推动血浆内成分药品化和输血医学治疗技术的发展提供基础。

关键词: 血浆, 异体共生, 拓展性应用, 蛋白组学

Abstract: Plasma is a commonly used component in clinical blood transfusion, primarily for supplementing coagulation factors to prevent or treat bleeding or bleeding tendencies caused by coagulation factor deficiencies. Convalescent plasma therapy have broadened the clinical application of plasma infusion. Research has shown that plasma infusion can also alleviate skin diseases and promote corneal regeneration. In animal experiments, it has been discovered that young plasma can combat aging and alleviate clinical manifestations of aging-related diseases by restoring autophagy, inhibiting apoptosis, reducing oxidative stress, and exerting anti-inflammatory effects. This article summarizes the progress of animal experimental research on the expanded applications of plasma and its related components except convalescent plasma therapy. It explores the potential molecular mechanisms underlying these expanded plasma applications, which provides foundation for advancing the commercialization of plasma components and the development of transfusion medicine treatment technology.

Key words: Plasma, Heterochronic parabiosis, Expansion applications, Proteomics

中图分类号:

R457.1⁺4

李津杞, 钱宝华, 许硕贵, 顾海慧. 血浆拓展性应用及相关成分研究进展^*[J]. 临床输血与检验, 2025, 27(2): 267-273.

LI Jinqi, QIAN Baohua, XU Shuogui, GU Haihui. Research Progress on Plasma Expansion Applications and Related Components[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(2): 267-273.

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血浆拓展性应用及相关成分研究进展^*

Research Progress on Plasma Expansion Applications and Related Components

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