• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (3): 412-422.DOI: 10.3969/j.issn.1671-2587.2025.03.021

• 综述 • 上一篇    下一篇

tsRNAs的生成及生物学功能研究进展*

刘悦, 刘瑶, 万九超, 管圣文, 赵攀   

  1. 川北医学院附属医院血液科, 四川南充 637000
  • 收稿日期:2024-12-20 发布日期:2025-06-23
  • 通讯作者: 赵攀,主要从事血液疾病研究,(E-mail)66716891@qq.com。
  • 作者简介:刘悦,主要从事血液疾病研究,(E-mail)liuyuee1219@163.com。
  • 基金资助:
    *本课题受四川省自然科学基金青年项目(No.2022NSFSC1416)资助

Advances in the Generation and Biological Function of tsRNAs

LIU Yue, LIU Yao, WAN Jiuchao, GUAN Shengwen, ZHAO Pan   

  1. Department of Hematology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000
  • Received:2024-12-20 Published:2025-06-23

摘要: 随着高通量测序技术的发展和生物信息学技术的进步,转运RNA(tRNA)衍生的小RNA(tsRNAs)作为一种新型的非编码小RNA受到了广泛的关注。根据核酸酶在tRNAs上切割位点的差异,tsRNAs可分为tRNA衍生片段(tRFs)、tRF-1、tRNA衍生的应激诱导小RNA(tiRNAs)和其他未分类的tsRNAs四大类,每一类都有特定的亚细胞定位。近年来的研究发现,tsRNAs在胚胎发育、细胞命运、免疫调控及多种人类疾病的发生发展中起着重要的作用。因此,本文系统性综述了tsRNAs的生物学起源及分类,tsRNAs的生物学功能,包括基因表达调控、翻译调控、表观遗传调控、逆转录调控和新生RNA沉默等,并探讨tsRNAs作为疾病诊断标志物和治疗靶点的可能性。

关键词: tsRNA, 非编码小RNA, tRF, tiRNA, 生物学功能

Abstract: With the development of high-throughput sequencing technology, the advancement of bioinformatics technology, transfer RNAderived small RNAshave received widespread attention as a novel type of non-coding small RNAs. Based on the differences in nuclease cleavage sites on tRNAs, tsRNAs can be classified into four major categories: tRNA-derived fragments, tRF-1, tRNA-derived stress-inducible small RNAs, other unclassified tsRNAs, each of which has a specific subcellular localization. Recent studies have revealed that tRNAs play important roles in embryonic development, cell fate, immune regulation, the development of many human diseases. Therefore, this paper systematically reviews the biological origin, classification of tsRNAs, the biological functions of tsRNAs, including gene expression regulation, translational regulation, epigenetic regulation, reverse transcriptional regulation, neonatal RNA silencing, explores the feasibility of tsRNAs as diagnostic markers, therapeutic targets for diseases

Key words: tsRNA, small non-coding RNA, tRF, tiRNA, biological function

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