血液冷凝集现象在新型冠状病毒感染中的研究进展

doi:10.3969/j.issn.1671-2587.2025.03.022

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (3): 423-426.DOI: 10.3969/j.issn.1671-2587.2025.03.022

血液冷凝集现象在新型冠状病毒感染中的研究进展

廖元梦, 何远

陆军军医大学第一附属医院检验科, 重庆 400038

收稿日期:2024-11-25 发布日期:2025-06-23
通讯作者: 何远,主要从事检验医学方面研究,（E-mail）hy1024@tmmu.edu.cn。
作者简介:廖元梦,主要从事检验医学方面研究,（E-mail）ym63362@163.com。

Blood Agglutination Phenomenon in COVID-19 Infection

LIAO Yuanmeng, HE Yuan

Department of Laboratory Medicine, First Affiliated Hospital of Army Medical University 400038

Received:2024-11-25 Published:2025-06-23

摘要/Abstract

摘要： 新型冠状病毒感染（COVID-19）可引起患者严重的呼吸系统症状,并可累及除呼吸系统外的多个系统病变;部分COVID-19患者在血常规检测或输血检测中可见血液出现冷凝集现象,且在疫情高发期具有增多趋势。其表现为冷凝集素滴度增高,血液出现凝集现象,少数患者发展为冷凝集素综合征和溶血反应。这种冷凝集素会严重影响血常规参数。因此,深入了解SARS-CoV-2感染后血液发生冷凝集现象的机制和特点,关注血液冷凝集样本检测结果的纠正,可为临床提供更加精准的检验结果。本文将对SARS-CoV-2感染中血液发生冷凝集现象的相关研究进展进行综述。

关键词: 冷凝集素, 冷凝集现象, 新型冠状病毒感染

Abstract: The coronavirus disease (COVID-19) is a severe respiratory infectious disease caused by the SARS-CoV-2 virus. It can cause multiple system diseases beyond the respiratory system. The phenomenon of cold agglutination in blood can be seen in routine tests or crossmatching in some COVID-19 patients, and it has an increasing trend in the peak epidemic period. This is characterized by increased cold agglutinin titers and blood agglutination, and a few patients develop cold agglutinin syndrome and hemolytic reactions. The cold agglutinin can significantly affect blood routine parameters. A thorough understanding of the mechanism and characteristics of cold agglutination after SARS-CoV-2 infection, as well as the correction of test results from blood cold agglutination samples, can provide more accurate results for clinical practice. This article will review the relevant research progress on cold agglutination in blood during SARS-CoV-2 infection.

Key words: Cold agglutinin, Cold agglutination phenomenon, COVID-19

中图分类号:

R512.99R446.11

廖元梦, 何远. 血液冷凝集现象在新型冠状病毒感染中的研究进展[J]. 临床输血与检验, 2025, 27(3): 423-426.

LIAO Yuanmeng, HE Yuan. Blood Agglutination Phenomenon in COVID-19 Infection[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(3): 423-426.

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血液冷凝集现象在新型冠状病毒感染中的研究进展

Blood Agglutination Phenomenon in COVID-19 Infection

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