• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)
临床输血与检验

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (5): 629-637.DOI: 10.3969/j.issn.1671-2587.2025.05.007

• 循证医学 • 上一篇    下一篇

成年人血清醛水平与贫血的相关性分析*

王菲1,2, 王海永3, 夏荣2   

  1. 1上海交通大学医学院附属仁济医院输血科,上海 200127;
    2复旦大学附属华山医院输血科,上海 200040;
    3南京中医药大学附属医院检验科,江苏南京 210000
  • 收稿日期:2025-09-02 修回日期:2025-09-09 出版日期:2025-10-20 发布日期:2025-10-11
  • 通讯作者: 夏荣,主要从事输血医学相关研究,（E-mail）rongxia@fudan.edu.cn。
  • 作者简介:王菲,主要从事输血医学相关研究,（E-mail）feiwang21@m.fudan.edu.cn。并列第一作者：王海永,主要从事临床检验诊断学研究,（E-mail）haiyongwang62@126.com。
  • 基金资助:
    *本课题受国家自然科学基金面上项目（No.82070197、No.82370232）资助

Association of Serum Isopentanaldehyde Level and Anemia in Adults

WANG Fei1,2, WANG Haiyong3, XIA Rong2   

  1. 1Department of Blood Transfusion, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127;
    2Department of Transfusion Medicine, Huashan Hospital, Fudan University, Shanghai 200040;
    3Department of Clinical Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210000
  • Received:2025-09-02 Revised:2025-09-09 Online:2025-10-20 Published:2025-10-11

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摘要： 目的 探讨真实世界中血清醛水平与贫血的相关性。方法 收集分析NHANES数据库成年人血清醛检测数据及全血血常规检测数据。结果 血清醛混合物与贫血呈现负向关联,其中异戊醛为醛混合物中最大促成作用亚类醛。在男性亚组中,异戊醛与中等区间贫血呈正向关联;在女性亚组中,异戊醛与轻度和重度区间贫血呈负向关联。在女性群体中,异戊醛每增加1 ng/mL血红蛋白浓度增高2.55 g/L（P=0.006）;在男性群体中,异戊醛每增加1 ng/mL红细胞计数下降0.114×1012/L（P=0.002）。结论 血清异戊醛与贫血存在一定相关性,且在男性女性中表现不同。对于血红蛋白浓度基本正常但呈现不明原因贫血症状的临床病例,异戊醛或可成为贫血潜在的辅助评估指标。

关键词: 血清醛, 异戊醛, 贫血, 红细胞, 血红蛋白

Abstract: Objective To explore association between serum aldehydes and red blood cell count and hemoglobin concentration in the real world. Methods The associations between serum aldehydes and anemia in US adults from the National Health and Nutrition Examination Survey were analyzed. Results Isopentanaldehyde was the primary contributor to the association between aldehyde exposure and anemia with the highest posterior inclusion probability value of 0.872. In addition, differential associations between isopentanaldehyde and anemia were identified in men and women. The isopentanaldehyde Q4 concentration exhibited a positive association with the anemia T2 group in the male population, while the isopentanaldehyde Q4 concentration manifested negative correlations with both the anemia T1 and T3 groups in the female population. Furthermore, each 1 ng/mL increment in isopentanaldehyde was associated with a 2.55 g/L increase in hemoglobin in females (P=0.006) and a 0.114×1012/L decrease in RBC count in males (P=0.002). Conclusion Serum isopentanaldehyde are related to anemia in adults in the real word and the association appeared difference between male and female groups. For cases with basically normal hemoglobin concentrations but presenting with unexplained anemia symptoms, isopentanaldehyde may become a pontential biomarker to assist evaluating disease status.

Key words: Serum aldehydes, Isopentanaldehyde, Anemia, Red blood cell, Hemoglobin

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