血源性滴眼液治疗干眼症的临床应用进展

doi:10.3969/j.issn.1671-2587.2025.05.020

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (5): 717-726.DOI: 10.3969/j.issn.1671-2587.2025.05.020

血源性滴眼液治疗干眼症的临床应用进展

王嘉欣¹, 王海莹², 陈立力², 黄永莉², 李卓豫², 邢颜超^1,2, 张进进^1,2

¹新疆医科大学研究生学院,乌鲁木齐 830054;
²新疆军区总医院输血科,乌鲁木齐 830000

收稿日期:2025-09-02 修回日期:2025-09-11 出版日期:2025-10-20 发布日期:2025-10-11
通讯作者: 张进进,主要从事临床输血与细胞治疗方面研究,（E-mail）13319805828@qq.com。共同通信作者：邢颜超,主要从事临床输血与细胞治疗方面研究,（E-mail）xingyanchao@aliyun.com。
作者简介:王嘉欣,主要从事临床检验与诊断学方面研究,（E-mail）2475013513@qq.com。

Progress in the Clinical Application of Blood-derived Eye Drops in the Treatment of Dry Eye Syndrome

WANG Jiaxin¹, WANG Haiying², CHEN Lili², HUANG Yongli², LI Zhuoyu², XING Yanchao^1,2, ZHANG Jinjin^1,2

¹School of Postgraduates, Xinjiang Medical University, Urumqi 830054;
²Department of Blood Transfusion, General Hospital of Xinjiang Military Command, Urumqi 830000

Received:2025-09-02 Revised:2025-09-11 Online:2025-10-20 Published:2025-10-11

摘要/Abstract

摘要： 干眼症（dry eye disease, DED）是一种由多因素介导的干燥性角结膜炎,其主要症状为眼睛干涩、视力模糊、灼烧感等,如治疗不及时可导致视力下降,严重者可伴剧烈疼痛甚至失明,对患者的生活质量造成严重影响。血源性滴眼液（blood-derived eye drops）来源于血液,内含多种生物活性因子,能够模拟天然泪液的生物活性,可润滑眼球表面、促进角膜上皮修复,并改善眼表炎症,用于治疗各种原因引起的眼部疾病。现有临床研究显示,使用血源性滴眼液可通过减轻角膜上皮损伤、促进角膜神经和细胞修复、增加泪液分泌和杯状细胞活性有效治疗干眼症。本文通过系统性检索PubMed、中国知网（CNKI）和万方数据（Wanfang Data）库,检索时限从建库至2025年7月。采用“干眼症”、“血源性滴眼液”、“自体血清”、“富血小板血浆”等中英文关键词进行检索。纳入已发表的临床研究（如随机对照试验、病例系列）,排除动物实验、综述、会议摘要及非单一疗法研究。通过对检索结果进行汇总分析,旨在为其临床应用提供科学参考。

关键词: 血源性滴眼液, 干眼症, 血清滴眼液, 血小板衍生物滴眼液

Abstract: Dry eye disease (DED) is a multifactorial mediated keratoconjunctivitis sicca, whose main clinical symptoms are dry eyes, blurred vision, burning sensation, etc., if not treated in time, it can lead to vision loss, and in severe cases, be accompanied by severe pain or even blindness, which seriously impacts patients. Blood-derived eye drops are derived from blood and contain a variety of bioactive factors, mimicking the biological activity of natural tears, which can lubricate the surface of the eyeball, promote corneal epithelial repair, and improve ocular surface inflammation, and are used to treat eye diseases caused by various causes. Existing clinical studies have shown that the use of blood-derived eye drops can effectively treat dry eye syndrome by reducing corneal epithelial damage, promoting corneal nerve and cell repair, and increasing tear secretion and goblet cell activity. This paper systematically searched the databases of PubMed, CNKI and Wanfang Data, and the search time period was from the establishment of the database to July 2025. Keywords such as "dry eye syndrome", "blood-derived eye drops", "autologous serum", and "platelet-rich plasma" were used to search in Chinese and English. Published clinical studies (e.g, randomised controlled trials, case series) were included, excluding animal trials, reviews, conference abstracts, and non-monotherapy studies. By conducting a summary analysis of the search results, it aims to provide a scientific reference for its clinical application.

Key words: Blood-derived eye drops, Dry eye syndrome, Serum eye drops, Platelet derivative eye drops

中图分类号:

R777R457

王嘉欣, 王海莹, 陈立力, 黄永莉, 李卓豫, 邢颜超, 张进进. 血源性滴眼液治疗干眼症的临床应用进展[J]. 临床输血与检验, 2025, 27(5): 717-726.

WANG Jiaxin, WANG Haiying, CHEN Lili, HUANG Yongli, LI Zhuoyu, XING Yanchao, ZHANG Jinjin. Progress in the Clinical Application of Blood-derived Eye Drops in the Treatment of Dry Eye Syndrome[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(5): 717-726.

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血源性滴眼液治疗干眼症的临床应用进展

Progress in the Clinical Application of Blood-derived Eye Drops in the Treatment of Dry Eye Syndrome

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