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临床输血与检验

临床输血与检验 ›› 2017, Vol. 19 ›› Issue (3): 243-245.DOI: 10.3969/j.issn.1671-2587.2017.03.010

• 临床输血 • 上一篇    下一篇

低效价不规则抗体漏检与红细胞输血无效关系探讨

张春丽, 牛梦林, 张改英   

  1. 100142 北京,北京大学肿瘤医院暨北京市肿瘤防治研究所输血科;
    恶性肿瘤发病机制及转化研究教育部重点实验室（张春丽,牛梦林）;
    包头市蒙医中医医院检验科（张改英）
  • 收稿日期:2016-10-29 出版日期:2017-06-20 发布日期:2017-06-23
  • 作者简介:张春丽（1985-）,女,内蒙古莫旗人,检验师,学士,主要从事输血相关工作,（ Tel）13810210186（ E-mail）zhangchunli0602@163.com。

The Ineffective RBCs Transfusion Caused by Undetectable and Irregular Antibodies

ZHANG Chun-li, NIU Meng-lin, ZHANG Gai-ying   

  1. Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education/Beijing）,Department of Blood Transfusion,Peking University Cancer Hospital & Institute,Beijing,100142
  • Received:2016-10-29 Online:2017-06-20 Published:2017-06-23

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摘要： 目的 探析红细胞输血无效与低效价不规则抗体漏检的相关性。方法 选择2014年6月~2015年4月临床输血患者1 987例,发现无效红细胞输血者196例,应用LISS/Coombs卡重新检测输血前样本,分析是否存在低效价不规则抗体情况。统计分析低效价不规则抗体与妊娠次数、输血次数、年龄、性别、输血不良反应等因素的关系。结果 1 987例临床输血病例出现红细胞输血无效196例（9.9%）,其中因低效价不规则抗体漏检引起输注无效30例（15.3%）。极易出现红细胞输血无效为妊娠次数≥3次（χ2=4.32,P=0.04）、输血次数≥3次（χ2=6.43,P=0.01）、男性（χ2=9.32,P<0.01）、年龄>60岁（χ2=6.74,P=0.01）及出现输血不良反应（尤其是迟发性输血反应）者。结论 低效价不规则抗体是输血无效的原因之一,与妊娠次数、妊娠史、输血次数、性别、年龄、输血不良反应等因素有关。

关键词: 红细胞输血无效, 不规则抗体, 低效价

Abstract: Objective Clinical observation and exploration of the relevance of the invalid red blood cells （RBCs） transfusion and the undetectable low titer and irregular antibodies. Methods One hundred and ninety-six patients with invalid RBCs transfusion were selected from 1 987 clinical cases frim Jun 2014 to April 2015. The ratio of low titer irregular antibodies in pre-transfusion samples was retested using LISS/Coombs cards. Simultaneously,the relationship between the lower titer irregular antibodies and pregnancy,volume of blood transfusion,ages,gender,adverse effect of transfusion,etc. Results The percentage of invalid RBCs transfusion in the 1987 cases of transfusionwas 9.9%,,among them,30 cases of undetectable low titer irregular antibodies were screened out. The ineffective RBCs transfusion and low titer irregular antibodies were closely related with the number of pregnancy （χ2=4.32,P=0.04）,volume of blood transfusions （χ2=6.43,P=0.01）,ages （χ2=6.74,P=0.01）,gender （χ2=9.32,P<0.01）,and adverse reactions of blood transfusion （χ2=4.33,P= 0.04）. Conclusion The low titer irregular antibodies is one of the reasons for invalid red blood transfusion,and closely related with the number of pregnancy,ages,gender,volume and adverse reactions of blood transfusion.

Key words: Invalid red blood cells transfusion, Irregular antibodies, Low titer

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