• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)

临床输血与检验 ›› 2017, Vol. 19 ›› Issue (5): 491-493.DOI: 10.3969/j.issn.1671-2587.2017.05.024

• 血型与临床 • 上一篇    下一篇

新疆北疆地区维吾尔族人群Duffy血型分布及基因频率调查*

古力巴哈提, 田雪梅, 邱芬, 阿斯木古丽, 迪娜尔, 施丽, 库丽曼   

  1. 833200 奎屯,新疆伊犁哈萨克自治州奎屯医院输血科(古力巴哈提,邱芬,阿斯木古丽,迪娜尔); 新疆伊犁哈萨克自治州友谊医院输血科(田雪梅,施丽,库丽曼)
  • 收稿日期:2017-03-13 出版日期:2017-10-20 发布日期:2017-10-26
  • 通讯作者: 邱芬,女,主要从事输血医学及血液免疫学研究,(E-mail)qiufen_kt@163.com。
  • 作者简介:古力巴哈提(1969-),女,哈萨克族,新疆哈巴河人,主管技师,主要从事临床输血工作,(Tel)0992-3286740
  • 基金资助:
    *本课题受新疆维吾尔自治区自然科学基金(No.201442137-24)资助

The Distribution of Gene Frequency of Duffy Blood Type in Uygur Population in the North Area of Xinjiang

Gulibahati, TIAN Xue-mei, QIU Fen, et al   

  1. Department of transfusion,Kuitun Hospital of Xinjiang's Ili Kazak Autonomous Prefecture,Kuitun 833200
  • Received:2017-03-13 Online:2017-10-20 Published:2017-10-26

摘要: 目的 了解新疆北疆地区维吾尔族人群Duffy血型表型的多态性,建立维吾尔族人群稀有血型抗原的资料,为临床科学、安全输血和预防新生儿溶血病提供参考依据。方法 随机抽取新疆北疆地区维吾尔族人群的无关个体894例,采用卡式微柱凝胶抗球蛋白法,进行Fya、Fyb抗原检测。结果 在894份标本中,Fy(a+b+)328例(36.69%),Fy(a+b-)494例(55.26%),Fy(a-b+)72例(8.05%),未检测出Fy(a-b-)标本。Fya基因频率为0.7360,Fyb基因频率为0.2640。经Hardy-Weinberg平衡检验,维吾尔族人群中Duffy血型系统抗原分布符合Hardy-Weinberg平衡。结论 新疆北疆地区维吾尔族人群Duffy血型系统抗原分布具有本民族独特的特征。

关键词: 维吾尔族, Duffy血型, 表型分布

Abstract: Objectives To investigate the polymorphism of Duffy blood type in Uygur population of Northern Xinjiang so as to establish the database of rare blood type antigens of Uighur population for prevention of hemolytic diseases of newborns. Methods The Fya and Fyb antigens were found in 894 randomly selected Uyghurs in the region when detected with the card gel antiglobulin method. Results In 894 specimens,328 Fy (a+b+) cases (36.69%),494 Fy (a+b-) cases (55.26%),and 72 Fy (a-b+) cases (8.05%) were seen but no Fy(a-b-) was observed. The frequencies of Fya and Fyb are 0.7360 and 0.2640,respectively. The distribution of Duffy blood group antigens is in accordance with the Hardy-Weinberg Equilibrium in the Uyghurs. Conclusion The distribution of Duffy blood group antigens of Uygur population in the north region of Xinjiang presents its racial characteristics.

Key words: Uygur, Duffy blood type, phenotype distribution

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