Abstract: Objective To explore the influence of exogenous glutamine（Gln）on the antioxidant enzymes. Methods Twenty two rats (specific pathogen free) were randomly divided into experimental group（A）,control group（B）,and standard group（C）. Animals of group A received gavage daily with alanyl-glutamine,group B with 0.9% normal saline,and group C were set up as control. Groups A and B were given gavage consecutively for 14 days. Blood specimens of rats of the three groups were detected for hydrogen peroxide enzyme（CAT）, superoxide dismutase（SOD）and glutathione oxidation reductase（GSH-Px）. Results The difference of CAT between groups A and C was statistically significant（P<0.05）, while the level of CAT at 14d of experimental group was significantly higher than the standard group（P<0.05）. The difference of GSH-Px between groups A and C was statistically significant（P<0.05）, no difference between groups A and B was found（P>0.05）.The level of GSH-Px at 14d of experimental group was remarkably higher than that of standard group（P<0.05）. No significant difference of SOD was noted among all of the three groups（P>0.05）. Conclusion Temperal administration of exogenous Gln may significantly increase CAT and GSH-Px levels, and serum SOD as well,thereby enhancing the ability to scavenge free radicals and antioxidant of the body.

Key words: Lipid peroxidation, Free radicals, Antioxidant enzyme, Hydrogen peroxide enzyme, Superoxide dismutase, Glutathione oxidation reductase, Glutamine