Abstract: Objective To analyze the gene frequency of killer cell immunoglobulin-like receptor （KIR） in Hebei Han population．Methods The blood samples of288unrelated Hebei Han individuals were genotyped by PCR-SSP method, gene frequency was analyzed. Results Among the Hebei Han population, framework gene KIR2DL4, 3DL2, 3DL3, 3DP1was found in all samples, 2DL1, 2DL3, 3DL1, 2DS4, 2DP1presented very high frequencies, genes2DL2, 2DS2, 2DS3, 2DS5presented low frequencies．A total of51KIR genotypes were identified, in which the genotype2DL4+3DP1+3DL2+3DL3+2DL1+2DL3+2DP1+3DL1+2DS4were predominant, with frequencies of43.75％. Conclusion The gene frequencies of KIR in Hebei Han population were similar to other Asian countries but significant differences with other national minority. The genotype2DL4+3DP1+3DL2+3DL3+2DL1+2DL3+2DP1+3DL1+2DS4was predominant．

Key words: KIR, Gene frequencies, Gene polymorphism