Abstract: Objective To investigate the correlation between tumor markers CA72-4 and pepsin levels and colchicine treatment in gout patients. Methods From January 2016 to July 2017 in 64 cases of gout in Department of Endocrinology and Rheumatology in our hospital，the patients were divided into two group according to whether or not colchicine was taken in the first two weeks before admission. The patient's general data were collected including gender，age，duration of disease，and levels of CA72-4，and pepsin. In order to exclude gastrointestinal and other tumors，electronic gastroscopy，electronic colonoscopy，abdominal color Doppler ultrasound examination were carried out. Results ①64 patients had history of gout and no tumor diseases. ②There was no significant difference between the two groups in sex，age，course of disease，ESR，UA，CRP and PCT. ③CA72-4 group was significantly higher than non - taking group （P<0.05）. After two weeks' withdrawal，the level of CA72-4 decreased significantly，the difference was statistically significant （P<0.05）. ④The difference of PGI between the two groups during the period of medication and after withdrawal was statistically significant，but there was no statistical difference between PGII and PGI/PGII. Conclusion Colchicine treatment in patients with gout may be associated with elevated CA72-4. Check CA72-4 after stopping medication to exclude the impact of drugs on the test results; Colchicine treatment of gout and PGI have a certainly relevance.

Key words: Gout , Colchicine, Carbohydrate antigen72-4 , Pepsin