Abstract: Objective To investigate the impact of neonatal transitional hypoglycemia on neurodevelopment in the infants at 18-months age. Methods Fifty-eight hospitalized infants with hypoglycemia were enrolled within 48 h after birth. The infants were given standardized management，aEEG detection，MRI scan，and assessed by using the Bayley Infant Development Scale （BSID） to 18 months after discharge. Results The median of hypoglycemia occurrence time after birth is 3.86 h（0.5～44 h），with the duration of 2.03±0.67 h，and venous blood glucose concentration was 1.62±0.37mmol/L. The first aEEG findings included disappeared sleep-wake cycles in 2 cases，immatures in 7 cases，and convulsions in 2 cases. The repeated aEEG examination revealed immature sleep-wake cycle in 2 cases. Brain MRI scans showed 7 abnormalities of 45 cases. BSID assessment of the infants at 18 months age demonstrated 93.91±6.35 of MDI and 95.86±7.27 of PDI. Spearman correlation analysis between blood glucose and MDI，PDI showed no obvious correlation （r：0.061，0.656，P>0.05）. The scatter diagram of each point presented mess disorder.Conclusions Developmental quotients of neonatal transitional hypoglycemia infants were normal at 18 months and were not associated with lowed blood glucose levels if they were received standardized blood glucose management after born. Long-term prognosis need further following-up.

Key words: Neonatal hypoglycemia , Amplitude integration EEG , Bayley infant development scale