Abstract: Objective To evaluate the value of serum and urinary retinol binding protein （RBP） and beta 2 microglobulin（2-MG） in neonatal hyperbilirubinemia. Methods From December 2014 to December 2016,the hospital treated 141 cases of neonatal hyperbilirubinemia,grading criteria of neonatal hyperbilirubinemia,47 cases with severe hyperbilirubinemia were included in the severe group,47 cases with extremely severe hyperbilirubinemia were inclued in the extremely severe group,and the risk hyperbilirubinemia group was included in the dangerous group,at the same period 47 cases of healthy neonates were selected as control group. Before and after treatment,serum and urine RBP,beta 2-MG and serum total bilirubin levels were measured before and 1 weeks after treatment. Results Four groups of patients before and after treatment,serum and urine RBP and beta 2-MG were statistically significant difference（P<0.05）,the control group,severe group,extremely severe group,and the risk group showed an increasing relationship; Before treatment and after treatment,serum total bilirubin levels were positively correlated with serum and urine RBP and beta 2-MG,among which urine RBP,beta 2-MG and serum total bilirubin levels were strongly correlated（r>0.6）. Conclusion The levels of serum and urine RBP,beta 2-MG levels were correlated with the severity of neonatal hyperbilirubinemia,and urinary RBP and beta 2-MG could assist in judging the severity of Hyperbilirubinemia.

Key words: Hyperbilirubinemia, Neonate, RBP, beta-2-MG