Abstract: Objective To investigate the characteristics of the amplitude-integrated electroencephalogram in the late preterm infants with hypoglycemia, and explore the effect of transient hypoglycemia on the brain function in late preterm infants. Methods From January 2015 to March 2016, 31 cases of late preterm infants with hypoglycemia admitted to our NICU were selected as hypoglycemia group（blood glucose level are 1.1~2.1 mmol/L, average is 1.7±0.3 mmol/L, after treatment, blood glucose return to normal within 2 hours）, all the objects were observed by aEEG monitoring on the day when hypoglycaemia was diagnosed or the day after. Over the same period, 24 cases with normoglycemia matched for gestation were selected randomly as control group, aEEG monitoring were done within 3 days after birth. The continuity of background, sleep-wake cycles, lower margin amplitude and bandwidth of all aEEG tracing were analyzed．Results （1）Continuity: The continuity of background were no significant difference between the two groups （P=0.756）. （2）Cycling: ①The total time history: hypoglycemia group was 77.8±20.3 minutes, the control group was 74.9±23.8 minutes, no statistical difference between the two groups （t=0.471, P=0.640）. ② Broadband time history: hypoglycemia group was 25.2±5.9 minutes, the control group was 24.2±6.2 minutes, no statistical difference between the two groups （t=0.614,P=0.542）. ③ Narrowband time history: hypoglycemia group was 52.6±18.6 minutes, the control group was 50.7±21.0 minutes, no statistical difference between the two groups （t=0.335, P=0.739）. （3）Lower margin amplitude: there was no statistical difference between the two groups in narrowband（P=0.451）. （4）Bandwidth: there were no statistical differences in both broadband （P=0.070） and narrowband（χ²=1.733,P=0.188）between the two groups. （5）Maturity score: there was no statistical difference between the two groups （t=-1.201,P=0.235）. （6）In the neurobehavioral assessment within 2 years of age, transient hypoglycemia was not found to cause developmental delay. Conclusion If the hypoglycemia in late preterm was transient hypoglycemia, there were no specificity aEEG changes.

Key words: Amplitude-integrated electroencephalogram, Hypoglycemia, Late preterm infant, Brain injury