Abstract: Objective To investigate the changes of serum calcium concentration（iCa） before and after massive transfusion，and discuss the influencing factors of the occurrence of hypocalcemia. Methods 75 cases of patients receiving massive blood transfusion in Xiangya Hospital from May 1，2015 to Apr 30，2016 were selected，collected serum calcium concentration of patients before and after massive transfusion，and analyzed changes of serum AG during massive transfusion，researched on the factors affecting the incidence of hypocalcemia. Results Student t test between groups showed that the serum calcium concentration（iCa） was significantly lower than that before the blood transfusion （P<0.05），iCa after the blood transfusion 24 hours rise again，but it was still lower than that before blood transfusion （P<0.05）. Logistic regression analysis showed that the amount of blood product input and AG after blood transfusion （blood acidity after transfusion） are important factors leading to the occurrence of hypocalcemia after massive transfusion，AG after blood transfusion is main influencing factor of the severity of hypocalcemia（P< 0.05）. Conclusion Hypocalcemia has direct relationships with the amount of blood products input （P＜0.05），while patients receiving massive transfusion have higher probability to suffer from hypocalcemia. Monitoring the change of iCa and blood pH closely during treatment can reduce the occurrence of hypocalcemia and other complications after massive transfusion.

Key words: Massive transfusion , Hypocalcemia, Blood tranfusion, Serum calcium