Abstract: Objective To investigate the relationships between missed abortion and age,autoimmune antibody,the history of spontaneous abortion among women after invitro fertilization-embryo transfer（IVF-ET）. Methods A retrospective analysis was made on 113 cases of chorionic chromosome examination in early abortion after IVF-ET from February 2016 to August 2018. Anti-nuclear antibody（ANA）,anti-cardiolipin antibody（ACA）,anti-thyroid peroxidase antibody（ATA） and anti-thyroglobulin antibody（ATG） were also detected. Results ①64 patients had normal chromosomes in 113 cases. Chromosome abnormalities were found in 49 cases. ②Chromosome abnormality rate of patients over 35 years old was significantly higher than that of patients under 35 years old（67.57% VS 31.58%,P<0.000 1）; ③There was no significant correlation between the history or times of early abortion and the chromosomal abnormalities. ④The positive rates of ACA,ANA and ATA/ATG in normal chromosome groups were higher than those in chromosomal abnormality groups,but without significant difference. Conclusion The rate of chromosome abnormalities increases with age. There is no significant relationship between the history of early abortion and the abnormalities of chorionic chromosomes after IVF-ET.

Key words: Chorionic chromosomes, IVF-ET, ACA, ANA, ATA, ATG