Abstract: Objective To investigate the effect of intravenous immunoglobulin for intravenous injection （IVIG） combined with antiviral regimen on the course and laboratory parameters of children with hand-foot-and-mouth disease （HFMD） complicated with encephalitis. Methods A total of 126 children with HFMD and encephalitis who were treated in our hospital from March 2016 to January 2018 were randomly divided into the control group and the observation group,with 63 cases in each group. The control group was given antiviral therapy,and the observation group was given IVIG on the basis of the control group for 3-5 days. The changes of laboratory indexes,course changes and clinical efficacy were observed in the two groups. Results There were no significant differences in age,gender,disease duration,child type,and place of residence between the two groups （P>0.05）. Beforetreatment,serum alkaline phosphatase （ALP）,prealbumin （PA）,white blood cell count （WBC）,C-reactive protein （CRP）,there was no significant difference between two groups in S100B,Neurospecific Enolase （NSE） and cerebrospinal fluid S100B and NSE （P>0.05）. After treatment,ALP and PA increased slightly in both groups. The group was slightly higher than the control group but the difference was not statistically significant （P>0.05）. WBC,CRP,serum S100B,serum NSE and cerebrospinal fluid S100B,cerebrospinal fluid NSE decreased,and the observation group was significantly lower than the control group. Academic significance （P<0.05）. The time of fever,rash regression time and recovery time of nervous system symptoms in the observation group were significantly shorter than the control group,and the difference was statistically significant （P<0.05）. The total effective rate was 77.78% in the control group and 96.82% in the observation group. The difference in clinical efficacy between the two groups was statistically significant （P<0.05）. Conclusion IVIG combined with antiviral treatment can improve the laboratory indicators of children with Hand-foot-mouth disease disease and encephalitis,shorten the recovering time and course of various clinical symptoms,and the clinical effect is remarkable.

Key words: Intravenous gamma globulin, Hand-foot-mouth disease, Encephalitis