Abstract: Objective To explore the correlation between serum DAPK, MGMT DNA methylation and pathological metastasis features of lung cancer. Methods From January 2015 to February 2018, 78 cases of non small cell lung cancer (NSCLC) were selected as observation group, and 100 healthy people as the control group at the same time in our hospital. The peripheral blood samples of two groups were collected, the plasma DNA methylation molecular markers-DAPK and MGMT levels were detected. Results The proportion of DAPK and MGMT methylation in the plasma samplesin the observation group were 51.3% and 53.8%, and those in the control group were 14% and 15% respectively, and observation group were significantly higher than those in the control group (P<0.05). In the observation group, there were significant correlation between plasma DAPK and MGMT methylation and histopathological type, lymph node metastasis and distal metastasis (P<0.05). Conclusion There are significant correlation between DAPK, MGMT methylation and the pathological features in the NSCLC patients.

Key words: DNA methylation, Molecular markers, Non-small cell lung cancer, Lymph node metastasis, Distal metastasis