Abstract: Objective To explore the correlation between the cytochrome p4502E1 gene transfer （CYP2EI） and glutathione enzyme sulfur MI （GSTM1） gene polymorphism and genetic susceptibility of non-small cell lung cancer in shenzhen area. Methods Samples were collected from February 2014 to October 2016 in shenzhen,every hospital and diagnosed with non-small cell lung cancer patients and at the same time all the 71 patients with lung benign disease in hospital,CYP2E1 gene was detected by PCR method then by the PCR-RFLP in RsaⅠ/PstⅠ,and the correlation between non-small cell lung cancer and gene polymorphism was analysed.Results There was no statistically significant difference between （χ²=0.891~1.205,P>0.05） non-small cell lung cancer and lung benign disease group patients in GSTM1 gene polymorphism,CYP2E1 gene Rsa I/Pst I polymorphisms of the three genotypes detection.;In non-small cell lung cancer group,GSTM1（-） genotype frequency was 61.79%,significantly higher than 36.62% of lung benign disease group,the difference was statistically significant in genetype frequency between two group （χ²=5.019,P<0.05）;The risk of non-small cell lung cancer is significantly higher in individual carrying GSTM1（-） genotypes than the GSTM1 （+） genotype individuals OR 2.095 （95% CI=1.104~3.173,P=0.032）;with cl/c2 and c2/c2 gene type of nonsmoking individuals,carrying the cl/cl genotypes of smokers significantly increased risk of non-small cell lung cancer （OR= 3.415,95% CI=1.092~11.214,P=0.028）; with cl/cl and GSTM1 （-） genotype individuals had a significantly higher risk of non-small cell lung cancer than individuals with GSTM1 （+） and cl/c2 and c2 / c2 genotype （（OR=3.518,95% CI=3.518~l2.812,P=0.045）.In the crowd,smoking is not allowed to carry GSTM1 （-） and cl/cl genotype had a significantly higher risk of non-small cell lung cancer with GSTM1 （+） and cl/c2 and c2 / c2 gene type of people （OR=2.917,95% CI=1.004~8.316,P=0.043）,and with GSTM1 （-） and cl/c2 and c2 / c2 gene type of crowd is higher than the same risk of non-small cell lung cancer with GSTM1 （+） and cl/c2 and c2 / c2 gene type of people （OR=14.062,95% CI=1.362~147.256,P=0.029）.Conclusion GSTM1 genotypes （-） is regarded as one of the risk factors for non small cell lung cancer were diagnosed in shenzhen area ; At the same time carrying CYP2E1 cl/cl and GSTM1 （-） genotypes can increase risk of non-small cell lung cancer in the smoking and nonsmoking population.

Key words: GSTM1, CYP2E1, Genetic polymorphism, Shenzhen, Non-small cell lung cancer, Susceptibility