Abstract: Objective Meta-analysis was used to systematically evaluate the blood transfusion strategies guided by Thromboelastography(TEG). Methods We searched computer-published randomized controlled trials (RCT) related to TEG-guided surgical blood transfusions published in PubMed, Web of Science, and ScienceDirect databases from January 1960 to July 2020, and we also manually searched for related papers. The quality of the included studies was assessed by two evaluation members according to the Cochrane collaboration network standard, and then the included studies were analyzed by RevMan 5.3 software. Results A total of 8 articles were included, involving a sample of 863 individuals, 366 cases in the test group and 497 cases in the control group. The meta-analysis results showed that there were no significant difference between test group and control group in Red blood cell (RBC) infusion rate and postoperative mortality. Test group could significant reduce the frequency of Platelet transfusion (P=0.02), the frequency of Fresh frozen plasma (FFP) transfusion(P<0.00001), the frequency of bleeding after surgery (P=0.006). Conclusions The application of TEG to guide blood transfusion during surgical operation can reduce the transfusion rate of Platelet and FFP, meanwhile reduce postoperative bleeding. It is an ideal blood transfusion guidance method.

Key words: Thromboelastography, Blood transfusions, Meta-analysis