Effect of Postoperative Chemotherapy on Peripheral Blood Lymphocyte Subsets in Elderly Patients with HER2 Positive Gastric Cancer

doi:10.3969/j.issn.1671-2587.2022.01.021

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2022, Vol. 24 ›› Issue (1): 93-96.DOI: 10.3969/j.issn.1671-2587.2022.01.021

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Effect of Postoperative Chemotherapy on Peripheral Blood Lymphocyte Subsets in Elderly Patients with HER2 Positive Gastric Cancer

ZHA Yan-fang, YUAN Qing-feng, HU Shou-xin, et al

West of the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Cancer Hospital), Hefei 230001

Received:2021-06-10 Published:2022-01-27

Abstract

Abstract: Objective We aim to clarify the changes of lymphocyte subsets in peripheral blood of elderly patients with gastric cancer before and after postoperative adjuvant chemotherapy, and to analyze the value of human epidermal growth factor receptor 2 (HER2) in the prognosis evaluation of elderly patients with gastric cancer. Methods The clinical data of 67 patients with gastric cancer who received postoperative adjuvant chemotherapy in the First Affiliated Hospital of University of Science and Technology of China from January 2017 to December 2019 were retrospectively collectedto analyze the number changes of white blood cells and lymphocyte subsets before and after chemotherapy in different age groups of HER2+ and HER2- gastric cancer patients. Results The frequency of HER2+ gastric cancer patients aged ≥60 was 45.2%, which was significantly higher than that in patients <60 years (12.0%), and the difference was significant (P=0.003). Further analysis showed that the absolute numbers of CD3+T, CD3+CD4+T and CD3+CD8+T cells in patients with gastric cancer aged≥60 years after the first chemotherapy were significantly lower than those before chemotherapy (P<0.05), and the absolute numbers of CD3+CD8+T cells in HER2+patients were significantly lower than those in HER2- patients after chemotherapy. At the same time, CD3-CD56+NK cells and CD4+CD25+Treg cells showed no significant changes before and after chemotherapy. In HER2-patients, however, chemotherapy did not affect the number of lymphocytes. Conclusion The proportion of HER2+ elderly patients (≥60 years) with gastric cancer was significantly increased. Compared with HER2- patients, adjuvant chemotherapy significantly inhibited the number of lymphocytes in HER2+patients, thus affecting the immune status of HER2+ patients. Therefore, it is speculated that precise immunotherapy or combination with low-dose chemotherapy is more suitable for elderly patients with HER2+ gastric cancer than traditional chemotherapy.

Key words: Gastric cancerPostoperative adjuvant chemotherapy, Human epidermal growth factor receptor 2, Peripheral blood lymphocytes, Age

CLC Number:

R735.2

ZHA Yan-fang, YUAN Qing-feng, HU Shou-xin, et al. Effect of Postoperative Chemotherapy on Peripheral Blood Lymphocyte Subsets in Elderly Patients with HER2 Positive Gastric Cancer[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24(1): 93-96.

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Effect of Postoperative Chemotherapy on Peripheral Blood Lymphocyte Subsets in Elderly Patients with HER2 Positive Gastric Cancer

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