Hydrogel-loaded PRP for the Treatment of Chronic Refractory Wounds

doi:10.3969/j.issn.1671-2587.2023.04.027

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2023, Vol. 25 ›› Issue (4): 564-571.DOI: 10.3969/j.issn.1671-2587.2023.04.027

Previous Articles Next Articles

Hydrogel-loaded PRP for the Treatment of Chronic Refractory Wounds

WANG Zilin, LIU Hongjie, ZHANG Ya, et al

School of Clinical Laboratory Science, Guizhou Medical University, Guiyang Guizhou Province 550001

Received:2023-05-05 Online:2023-08-20 Published:2023-09-18

Abstract

Abstract: The treatment of chronic non-healing wounds remain challenging in terms of complexity. Although platelet rich plasma (PRP) therapy has been widely proven effective, the traditional method of in vitro activation of PRP leads to the rapid release of all growth factors. Due to the separation of colloid and supernatant after activation, the factor-rich supernatant is easy to flow and lose, and it is difficult to form a stable structure, which affects its therapeutic effect. To overcome this problem, researchers in recent years have explored hydrogels as carriers for PRP to improve the shortcomings of traditional PRP treatment. This article reviews the latest research on hydrogel-loaded PRP for the treatment of chronic non-healing wounds and provides a reference for optimal treatment.

Key words: Platelet rich plasma, Hydrogel, Chronic refractory wounds

CLC Number:

R457

WANG Zilin, LIU Hongjie, ZHANG Ya, et al. Hydrogel-loaded PRP for the Treatment of Chronic Refractory Wounds[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(4): 564-571.

References

[1] SCHILRREFF P,ALEXIEV U.Chronic inflammation in non-healing skin wounds and promising natural bioactive compounds treatment[J].Int J Mol Sci,2022,23(9):4928.
[2] TANAKA R,INOUE H,ISHIKAWA T,et al.Use of sponge-foam inserts in compression bandaging of non-healing venous leg ulcers[J].Ann Vasc Dis,2021,14(1):46-51.
[3] RODRÍGUEZ-RODRÍGUEZ N,MARTÍNEZ-JIMÉNEZ I,GARCÍA-OJALVO A,et al.Wound chronicity,impaired immunity and infection in diabetic patients[J].MEDICC Rev,2021,24(1):44-58.
[4] LI S X,MOHAMEDI A H,SENKOWSKY J,et al.Imaging in chronic wound diagnostics[J].Adv Wound Care,2020,9(5):245-263.
[5] ALVEN S,ADERIBIGBE B A.Chitosan and cellulose-based hydrogels for wound management[J].Int J Mol Sci,2020,21(24):9656.
[6] 谭谦,徐晔.慢性创面治疗的理论和策略[J].中华烧伤杂志,2020,36(9):798-802.
[7] WANG Y H, WANG Z L, et al.ZHANG Y.Platelet-Rich Plasma Reduces LPS-Stimulated Inflammatory Reaction in BV2 Cells by Blocking the TLR4-Mediated NF-κB/MAPKs Pathway[J].Journal of Biological Regulators and Homeostatic Agents,2023, 37(4):2159-2170
[8] EVERTS P,ONISHI K,JAYARAM P,et al.Platelet-rich plasma:new performance understandings and therapeutic considerations in 2020[J].Int J Mol Sci,2020,21(20):7794.
[9] EVERTS P A,VAN ERP A,DESIMONE A,et al.Platelet rich plasma in orthopedic surgical medicine[J].Platelets,2021,32(2):163-174.
[10] SIMONPIERI A,DEL CORSO M,VERVELLE A,et al.Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 2:bone graft,implant and reconstructive surgery[J].Curr Pharm Biotechnol,2012,13(7):1231-1256.
[11] OPNEJA A,KAPOOR S,STAVROU E X.Contribution of platelets,the coagulation and fibrinolytic systems to cutaneous wound healing[J].Thromb Res,2019,179:56-63.
[12] GOLEBIEWSKA E M,POOLE A W.Platelet secretion:from haemostasis to wound healing and beyond[J].Blood Rev,2015,29(3):153-162.
[13] JOHN A E,WHITE N J.Platelets and fibrinogen:emerging complexity in trauma-induced coagulopathy[J].Semin Thromb Hemost,2020,46(2):125-133.
[14] UCHIYAMA R,TOYODA E,MAEHARA M,et al.Effect of platelet-rich plasma on M1/M2 macrophage polarization[J].Int J Mol Sci,2021,22(5):2336.
[15] PICCIN A,DI PIERRO A M,CANZIAN L,et al.Platelet gel:a new therapeutic tool with great potential[J].Blood Transfus,2017,15(4):333-340.
[16] 付丹妹,孙诚,陈建民,等.负压创面治疗联合富血小板血浆治疗慢性难愈性创面的研究进展[J].医学研究生学报,2022,35(2):196-201.
[17] PHILLIPSON M,KUBES P.The healing power of neutrophils[J].Trends Immunol,2019,40(7):635-647.
[18] AGGOUR R L,GAMIL L.Antimicrobial effects of platelet-rich plasma against selected oral and periodontal pathogens[J].Pol J Microbiol,2017,66(1):31-37.
[19] LIU X L,YANG Y L,NIU X,et al.An in situ photocrosslinkable platelet rich plasma - Complexed hydrogel glue with growth factor controlled release ability to promote cartilage defect repair[J].Acta Biomater,2017,62:179-187.
[20] GOODWIN N S,SPINKS A,WASIAK J.The efficacy of hydrogel dressings as a first aid measure for burn wound management in the pre-hospital setting:a systematic review of the literature[J].Int Wound J,2016,13(4):519-525.
[21] ZHANG L J,YIN H X,LEI X,et al.A systematic review and meta-analysis of clinical effectiveness and safety of hydrogel dressings in the management of skin wounds[J].Front Bioeng Biotechnol,2019,7:342.
[22] HO T C,CHANG C C,CHAN H P,et al.Hydrogels:proper ti es and applications in biomedicine[J].Molecules,2022,27(9):2902.
[23] OSI A R,ZHANG H,CHEN J,et al.Three-dimensional-printable thermo/photo-cross-linked methacrylated chitosan-gelatin hydrogel composites for tissue engineering[J].ACS Appl Mater Interfaces,2021,13(19):22902-22913.
[24] LEI X X,HU J J,ZOU C Y,et al.Multifunctional two-component in situ hydrogel for esophageal submucosal dissection for mucosa uplift,postoperative wound closure and rapid healing[J].Bioact Mater,2023,27:461-473.
[25] ITAI S,ONOE H.Flexibly deformable collagen hydrogel tube reproducing immunological tissue deformation of blood vessels as a pharmacokinetic testing model (adv.healthcare mater.1/2022)[J].Adv Healthc Mater,2022,11(1):2270005.
[26] LUECKGEN A,GARSKE D S,ELLINGHAUS A,et al.Hydrolytically-degradable click-crosslinked alginate hydrogels[J].Biomaterials,2018,181:189-198.
[27] FRIEND N E,MCCOY A J,STEGEMANN J P,et al.A combination of matrix stiffness and degradability dictate microvascular network assembly and remodeling in cell-laden poly(ethylene glycol) hydrogels[J].Biomaterials,2023,295:122050.
[28] YANG K,ZHOU X Y,LI Z L,et al.Ultrastretchable,self-healable,and tissue-adhesive hydrogel dressings involving nanoscale tannic acid/ferric ion complexes for combating bacterial infection and promoting wound healing[J].ACS Appl Mater Interfaces,2022,14(38):43010-43025.
[29] GARCIA-ORUE I,SANTOS-VIZCAINO E,SANCHEZ P,et al.Bioactive and degradable hydrogel based on human platelet-rich plasma fibrin matrix combined with oxidized alginate in a diabetic mice wound healing model[J].Mater Sci Eng C Mater Biol Appl,2022,135:112695.
[30] SUN Z H,XIONG H,LOU T F,et al.Multifunctional extracellular matrix hydrogel with self-healing properties and promoting angiogenesis as an immunoregulation platform for diabetic wound healing[J].Gels,2023,9(5):381.
[31] MA S Q,HU H,WU J Z,et al.Functional extracellular matrix hydrogel modified with MSC-derived small extracellular vesicles for chronic wound healing[J].Cell Prolif,2022,55(4):e13196.
[32] SONG F Y,KONG Y,SHAO C Y,et al.Chitosan-based multifunctional flexible hemostatic bio-hydrogel[J].Acta Biomater,2021,136:170-183.
[33] FAROKHI M,MOTTAGHITALAB F,FATAHI Y,et al.Overview of silk fibroin use in wound dressings[J].Trends Biotechnol,2018,36(9):907-922.
[34] GYEONGWOO L,GWANG K Y,HYUN B K,et al.Green tea catechin-grafted silk fibroin hydrogels with reactive oxygen species scavenging activity for wound healing applications[J].Biomater Res,2022,26(1):62.
[35] HEMMATGIR F,KOUPAEI N,POORAZIZI E.Characterization of a novel semi-interpenetrating hydrogel network fabricated by polyethylene glycol diacrylate/polyvinyl alcohol/tragacanth gum as a wound dressing[J].Burns,2022,48(1):146-155.
[36] LAURANO R,BOFFITO M,ABRAMI M,et al.Dual stimuli-responsive polyurethane-based hydrogels as smart drug delivery carriers for the advanced treatment of chronic skin wounds[J].Bioact Mater,2021,6(9):3013-3024.
[37] POGOSTIN B H,YU M H,AZARES A R,et al.Multidomain peptide hydrogel adjuvants elicit strong bias towards humoral immunity[J].Biomater Sci,2022,10(21):6217-6229.
[38] LOPEZ-SILVA T L,CRISTOBAL C D,EDWIN LAI C S,et al.Self-assembling multidomain peptide hydrogels accelerate peripheral nerve regeneration after crush injury[J].Biomaterials,2021,265:120401.
[39] ZHANG W L,LIU Y N,XUAN Y,et al.Synthesis and applications of carboxymethyl cellulose hydrogels[J].Gels,2022,8(9):529.
[40] WEI L,TAN J Y,LI L,et al.Chitosan/alginate hydrogel dressing loaded FGF/VE-cadherin to accelerate full-thickness skin regeneration and more normal skin repairs[J].Int J Mol Sci,2022,23(3):1249.
[41] CATOIRA M C,FUSARO L,DI FRANCESCO D,et al.Overview of natural hydrogels for regenerative medicine applications[J].J Mater Sci Mater Med,2019,30(10):115.
[42] OUYANG Q Q,HU Z,LIN Z P,et al.Chitosan hydrogel in combination with marine peptides from tilapia for burns healing[J].Int J Biol Macromol,2018,112:1191-1198.
[43] OUYANG Q Q,HOU T T,LI C P,et al.Construction of a composite sponge containing tilapia peptides and chitosan with improved hemostatic performance[J].Int J Biol Macromol,2019,139:719-729.
[44] VENKATESAN J,PALLELA R,BHATNAGAR I,et al.Chitosan-amylopectin/hydroxyapatite and chitosan-chondroitin sulphate/hydroxyapatite composite scaffolds for bone tissue engineering[J].Int J Biol Macromol,2012,51(5):1033-1042.
[45] OUYANG Q Q,KONG S Z,HUANG Y M,et al.Preparation of nano-hydroxyapatite/chitosan/tilapia skin peptides hydrogels and its burn wound treatment[J].Int J Biol Macromol,2021,181:369-377.
[46] BARRERA J A,TROTSYUK A A,MAAN Z N,et al.Adipose-derived stromal cells seeded in pullulan-collagen hydrogels improve healing in murine burns[J].Tissue Eng A,2021,27(11/12):844-856.
[47] YANG X F,YANG H Y,JIANG X Y,et al.Injectable chitin hydrogels with self-healing property and biodegradability as stem cell carriers[J].Carbohydr Polym,2021,256:117574.
[48] JAVANBAKHT S,NABI M,SHADI M,et al.Carboxymethyl cellulose/tetracycline@UiO-66 nanocomposite hydrogel films as a potential antibacterial wound dressing[J].Int J Biol Macromol,2021,188:811-819.
[49] WU J A,HOU S Y,REN D C,et al.Antimicrobial properties of nanostructured hydrogel webs containing silver[J].Biomacromolecules,2009,10(9):2686-2693.
[50] 何勍,吴钢,余波,等.伤口愈合水凝胶治疗慢性下肢静脉曲张性溃疡的早期结果[J].中国修复重建外科杂志,2008,22(3):311-313.
[51] 刘震杰,符伟国.静脉性溃疡的敷料选用[J].中国普外基础与临床杂志,2009,16(6):439-440.
[52] BASTIANCICH C,VANVARENBERG K,UCAKAR B,et al.Lauroyl-gemcitabine-loaded lipid nanocapsule hydrogel for the treatment of glioblastoma[J].J Control Release,2016,225:283-293.
[53] UHART M,PIROT F,BOILLON A,et al.Assessment of sodium hyaluronate gel as vehicle for intracameral delivery of cefuroxime in endophthalmitis prophylaxis[J].Int J Pharm,2010,398(1/2):14-20.
[54] DUMAN G,ASLAN İ,YEKTA ÖZER A,et al.Liposome,g el and lipogelosome formulations containing sodium hyaluronate[J].J Liposome Res,2014,24(4):259-269.
[55] QIAO Z Q,ZHANG W J,WU Y M,et al.Host defense peptide-mimicking peptide polymer-based antibacterial hydrogel enables efficient healing of MRSA-infected wounds[J].Sci China Chem,2023,66(6):1824-1833.
[56] HUANG K,LIU W B,WEI W Y,et al.Photothermal hydrogel encapsulating intelligently bacteria-capturing bio-MOF for infectious wound healing[J].ACS Nano,2022,16(11):19491-19508.
[57] JIANG Y F,RAN X W,JIA L J,et al.Epidemiology of type 2 diabetic foot problems and predictive factors for amputation in China[J].Int J Low Extrem Wounds,2015,14(1):19-27.
[58] XU N,WANG L L,GUAN J J,et al.Wound healing effects of a Curcuma zedoaria polysaccharide with platelet-rich plasma exosomes assembled on chitosan/silk hydrogel sponge in a diabetic rat model[J].Int J Biol Macromol,2018,117:102-107.
[59] MORIMOTO N,KAKUDO N,MATSUI M,et al.Exploratory clinical trial of combination wound therapy with a gelatin sheet and platelet-rich plasma in patients with chronic skin ulcers:study protocol[J].BMJ Open,2015,5(5):e007733.
[60] PEREZ-LOPEZ S,PEREZ-BASTERRECHEA M,GARCIA-GALA J M,et al.Stem cell and tissue engineering approaches in pressure ulcer treatment[J].J Spinal Cord Med,2023,46(2):194-203.
[61] LU K,LI K K,ZHANG M,et al.Adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) loaded gelatin/silk fibroin hydrogels for improving healing in a murine pressure ulcer model[J].Chem Eng J,2021,424:130429.
[62] 许育兵,刘广亚,施琳颖,等.载血小板凝胶上清复合可吸收敷料对大鼠烧伤创面的修复作用[J].中国输血杂志,2019,32(11):1102-1105.
[63] ZHU X R,KAZEMI A,DONG Y Q,et al.Effectiveness of nano bioactive glass fiber loaded with platelet-rich plasma on thermal wound healing process in rats[J].J Biomed Nanotechnol,2022,18(2):535-545.
[64] MUTHUSWAMY S,VISWANATHAN A,YEGAPPAN R,et al.Antistaphylococcal and neutrophil chemotactic injectable κ-carrageenan hydrogel for infectious wound healing[J].ACS Appl Bio Mater,2019,2(1):378-387.
[65] WEI S K,XU P C,YAO Z X,et al.A composite hydrogel with co-delivery of antimicrobial peptides and platelet-rich plasma to enhance healing of infected wounds in diabetes[J].Acta Biomater,2021,124:205-218.
[66] SHI L Y,LIN F,ZHOU M,et al.Preparation of biocompatible wound dressings with dual release of antibiotic and platelet-rich plasma for enhancing infected wound healing[J].J Biomater Appl,2021,36(2):219-236.

Hydrogel-loaded PRP for the Treatment of Chronic Refractory Wounds

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 3

Recommended Articles

Metrics

Comments

About

Author

Journal

Access Statistics

Contact

[1]	XIAO Jun, LEI Huifeng, LI Cuiying. The Differential of Growth Factor Expression Profile in Platelet-rich Plasma Lysate and Platelet Gel [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(4): 450-455.
[2]	GONG Mimi, WANG Haining, WU lei, et al. Efficacy of Allogeneic Platelet Rich Plasma for Chronic Refractory Wounds [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(3): 368-374.
[3]	WEI Yan, LIU Kuan, LI Xiang-jun, et al. Observation on the Therapeutic Effect of PRP in the Treatment of Traumatic Synovitis of Ankle Joint [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24(6): 725-729.