Abstract: Objective To observe the diagnostic value of low hemoglobin density (low hemoglobin density, LHD) for iron deficiency anemia (iron deficiency anemia, IDA) and iron deficiency (iron deficiency, ID) in hemodialysis anemia patients, and to clarify the clinical application value of LHD in the differential diagnosis of anemia of different causes in hemodialysis patients. Methods 375 maintenance hemodialysis patients in Longgang Central Hospital from January 2020 to January 2022 were divided into: hemodialysis non-anemia group, renal anemia, renal anemia and iron normal group, renal anemia and absolute iron deficiency group, renal anemia and functional iron deficiency group. At the same time, 157 people from health examination and 65 people with iron deficiency anemia in Longgang Central Hospital were selected as healthy control group (negative control group) and iron deficiency anemia group (positive control group) respectively. The differences in red blood cell parameters LHD and iron metabolism were analyzed among the groups. ROC curve analysis of the diagnostic power of LHD in IDA and ID was tested in the hemodialysis anemia population. Results In IDA screening, the diagnostic value of LHD was> 23.05 (P<0.05), sensitivity 100% and specificity 99.49%. For screening of functional iron deficiency in the hemodialysis anemia population,, its the diagnostic value> 7.705 (P<0.05), sensitivity 61.11% and specificity 58.67%. Conclusion sLHD has high diagnostic efficacy for IDA in hemodialysis anemia patients with diagnostic threshold> 23.05. LHD is weak in diagnose ID in patients with hemodialysis anemia.LHD has no obvious differential diagnosis value for renal anemia combined with functional iron deficiency and absolute iron deficiency.

Key words: Low hemoglobin density, Iron deficiency anemia, Iron deficiency Hemodialysis