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JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2024, Vol. 26 ›› Issue (6): 825-834.DOI: 10.3969/j.issn.1671-2587.2024.06.019

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Platelet-derived Products in Wound Healing

WANG Shujun, LI Zhaojie, YANG Yi, LUAN Jianfeng   

  1. Department of Blood Transfusion, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002
  • Received:2024-08-05 Online:2024-12-20 Published:2024-12-20

Abstract: Platelets play a crucial role in a variety of physiologic and pathologic processes, especially in hemostasis and wound healing. In recent years platelet-rich plasma, platelet-rich fibrin, platelet-lysate and other platelet-derived products have become a promising treatment in regenerative medicine and have been widely applied clinically. By release a variety of growth factors, cytokines, and chemokines, platelet-derived products induce cell migration, proliferation, differentiation, and chemotaxis, stimulating mitosis in multiple cell types and neovascularization, increasing endothelial cell response to pro-angiogenic factors, and promoting fibroblast migration and proliferation. This article reviews the classification and origin of platelet-derived products, biological characteristics of the main growth factors, and their therapeutic effects in promoting the healing of various wounds, then, also analyzed the possible issues and the future development possibilities.

Key words: Platelet-derived products, Wound healing, Growth factor

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