Abstract: Objective To investigate the levels and clinical significance of platelet factor 4 （PF4）,vascular endothelial growth factor（VEGF）,hypoxia inducible factor-1α（HIF-1α） and lipoprotein α（Lp α） in hepatocellular carcinoma （HCC）. Method The investigation included 102 inpatients of chronic hepatitis B（HCB）,51 of liver cirrhosis,37 of HCC,and 186 subjects of healthy controls（HC） between 2014 and 2016. All samples were detected with immune enhanced turbidimetric method for serum concentration of Lpα and with ELISA for seral PF4,HIF - la and VEGF. Results The PF4,VEGF,HIF-1a and Lpα concentrations in HCC patients were obviously higher than those of CHB and LC patients,and HC as well （P<0.001~0.05）,showing a stage-dependent increase of the markers tested（t=7.951-19.086,P<0.001-0.05）. No remarkable variation was noted of PF4,VEGF,and HIF-1α in the three groups（P>0.05）. Lpαlevel,however,was found to be higher in LC group than in the other groups（P<0.05）,reversely showing a stage-dependent decrease（P<0.05）. Conclusion sPF4,VEGF,HIF-1α and Lpαlevels are significantly elevated in the sera of HCC patients,based on which a differential diagnosis between LC and HCC can be made.

Key words: Platelet factor-4, Vascular endothelial growth factor, Hypoxia inducible factor-1α, Lipoprotein（a）, Hepatocellular carcinoma