Abstract: Objective To study significance of combined detection of serum retinol binding protein （RBP） and urine alpha 1 microglobulin （alpha 1-MG）,albumin （mALB） in assessment of renal function and prognosis in patients with chronic glomerulonephritis. Methods The 50 cases were randomly selected from patients with chronic glomerulonephritis undergoing implementation method of treatment as the research object in our hospital in December 2013 -2014 year in December,as the observation group,and randomly 50 cases of healthy persons were selected as control group at the same period. RBP,1-MG and mALB alpha were detected in two groups,the correlation between above indicators and the damage of kidney function or prognosis of patients were analyzed. Results Compared with the control group,there was higher level of RBP,a 1-MG and mALB in patients from the observation group with significantlydifference （t=8.6225,9.3614,11.2416,P<0.05）; RBP,mALB and alpha 1-MG levels were significantly higher in patients with chronic renal failure than in those slow or no progress （t=7.9854,8.6354,10.5241,P<0.05）,the change of RBP,alpha 1-MG and mALB level is proportional to the prognosis effect ; and compared to separate evaluation,sensitivity and specificity are significantly higher in ROC of RBP,a 1-MG and mALB curve of joint detection area. Conclusion Three indexes of RBP,1-MG and mALB alpha has important application value in the evaluation of renal function in patients with chronic glomerulonephritis damage effect and prognosis,and three indicators combined detection is helpful to improve the accuracy of clinical assessment,it is worthy of popularization and application.

Key words: Serum retinol binding protein, Urine alpha 1 microspheres, Microalbuminuria, Chronic glomerulonephritis, Renal impairment, Prognosis