Abstract: Objective To explore the clinical significance of combined detection of SCC,CEA and CYFRA211 for early cervical cancer screening. Methods 108 patients with high risk of cervical cancer screened in our hospital were divided into cervical cancer group（67 cases） and Cervix benign disease group（41 cases）,and 82 healthy people who had physical examinationin our hospital at the same period were selected as the control group,and the normal cervix was tested by TCT test. 3-5mL blood were collectedfrom all ofsubjects ,and levels of squamous cell carcinomaantigen （SCC）,cytokeratin 19 fragment （CYFRA211） and carcinoembryonic antigen （CEA） were measured by chemiluminescence. The serum SCC,CEA and CYFRA211 single item detection or joint detection of tumor markers to the cervix in the cervix was compared. Results Levels of serum SCC,CYFRA211 and CEA in the cervical cancer group were higher than those of the benign cervical disease group and the control group,and the cervical benign disease group were higher than the control group,the difference were statistically significant （P<0.05）. The serum levels of SCC,CYFRA211 and CEA in the low differentiation group were higher than the middle differentiation group and the high differentiation group,and the middle differentiation group was higher than the high differentiation group,and the difference was statistically significant （P<0.05）. Serum SCC and CYFRA211 levels in squamous carcinoma group were higher than adenocarcinoma group and squamous adenocarcinoma group,serum CEA level in adenocarcinoma group were higher than squamous carcinoma group and squamous adenocarcinoma group （P<0.05）. There was no difference in serum SCC and CYFRA211 between adenocarcinoma group and squamous adenocarcinoma group. There was no difference in serum CEA between squamous carcinoma group and squamous adenocarcinoma group. The sensitivity,specificity,positive predictive value and negative predictive value were higher than those of single detection of serum SCC,CEA or CYFRA211,and the difference was statistically significant （P<0.05） when the three groups were combined to detect the cervical cancer screening standard. Conclusion The combined detection of serum SCC,CEA and CYFRA211 has clinical significance for early cervical cancer screening,and is helpful for differentiation of early cervical cancer and differential diagnosis of pathological types.

Key words: SCC, CYFRA211, CEA, Early cervical cancer screening