Abstract: Objective To study the clinical effect of cardiopulmonary resuscitation combined with salvia miltiorrhiza ligustrazine injection in the treatment of emergency craniocerebral injury and its effect on GCS score and Apache Ⅱ score.Methods152 patients admitted in our hospital from March 2013 to March 2018 were randomly divided into two groups: observation group （n=76） and control group （n=76）.The control group was treated with cardiopulmonary resuscitation and symptomatic support,while the observation group was treated with salvia miltiorrhiza ligustrazine injection on the basis of the control group.Treatment 7 days. The indexes of hemodynamics,lactic acid,GCS and Apache Ⅱ,brain edema area and prognosis were compared between the two groups.Results Before treatment,there was no difference in TK,Fi,MST,lactic acid,blood glucose,APTT,TT,PT level and brain edema area between the two groups （P>0.05）. After treatment,the levels of MST,Fi,lactic acid,blood glucose,APTT,TT,PT and brain edema in the observation group were lower than those in the control group（t=8.262,P<0.05;t=7.757,P<0.05;t=10.127,P<0.05;t=3.526,P<0.05;t=9.162,P<0.05;t=8.447,P<0.05;t=9.142,P<0.05;t=29.015,P<0.05）.The level of TK is higher in the observation groupthan that in the control group（t=9.698,P<0.05）.After 3 months of treatment,the rate of good and moderate disability in the observation group was 76.32%,which was higher than that in the control group （55.26%）（χ²=7.480,P<0.05）.Conclusion Cardiopulmonary resuscitation combined with salvia miltiorrhiza ligustrazine injection has a good clinical effect in the treatment of emergency craniocerebral injury.

Key words: Cardiopulmonary resuscitation, Radix Salviae Miltiorrhizae Chuanxiong injection, Craniocerebral injury, GCS score, Apache Ⅱ, score