Research Progress of Autologous Platelet-rich Plasma in Treatment of Discogenic Low Back Pain

doi:10.3969/j.issn.1671-2587.2024.06.022

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2024, Vol. 26 ›› Issue (6): 849-854.DOI: 10.3969/j.issn.1671-2587.2024.06.022

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Research Progress of Autologous Platelet-rich Plasma in Treatment of Discogenic Low Back Pain

WANG Zuhua, ZHOU Guojun, FAN Jinbo, LIU Jiubo

Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000

Received:2024-04-11 Online:2024-12-20 Published:2024-12-20

Abstract

Abstract: Discogenic low back pain (DLBP) is the most common type of low back pain in clinical practice, which is one of the most causes of disability and loss of productivity, and has a serious impact on the daily work and life of patients. PRP (platelet-rich plasma, PRP) is derived from autologous tissue, with various bioactive factors in the closest components to the body. It does not produce any immune response, is convenient to obtain, and low cost. Recent studies have shown that it contains rich growth factors that can promote the proliferation of cells and tissues in intervertebral discs, and has a significant promoting effect on intervertebral disc regeneration. This article reviews the pathogenesis of DLBP, the principle of PRP treatment for DLBP, and the clinical application of PRP, which could provide an new idea for the clinical treatment of DLBP.

Key words: Platelet-rich plasma, Discogenic low back pain, Research progress

CLC Number:

R457

WANG Zuhua, ZHOU Guojun, FAN Jinbo, LIU Jiubo. Research Progress of Autologous Platelet-rich Plasma in Treatment of Discogenic Low Back Pain[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2024, 26(6): 849-854.

References

[1] KIM H S,WU P H,JANG I T.Lumbar degenerative disease part 1:anatomy and pathophysiology of intervertebral discogenic pain and radiofrequency ablation of basivertebral and sinuvertebral nerve treatment for chronic discogenic back pain:a prospective case series and review of literature[J]. Int J Mol Sci,2020,21(4):1483.
[2] 周杨,葛韧,张远,等. 椎间盘造影在诊断椎间盘源性腰痛中的应用[J]. 临床骨科杂志,2024,27(1):16-19.
[3] 韦永安,李波,张强,等. 富血小板血浆治疗腰椎间盘退行性变的研究现状和前景展望[J]. 风湿病与关节炎,2022,11(6):77-80.
[4] 彭兵,杜立龙,张同星,等. 椎间盘源性腰痛的发病机制与治疗进展[J]. 中国矫形外科杂志,2023,31(16):1488-1492.
[5] 高夕林,吴思,张超,等.椎间盘退变中的力学信号转导蛋白[J].中国组织工程研究,2025,29(03):579-589.
[6] JOHNSON W E,CATERSON B,EISENSTEIN S M,et al.Human intervertebral disc aggrecan inhibits nerve growth in vitro[J]. Arthritis Rheum,2002,46(10):2658-2664.
[7] HUKINS D W L,MEAKIN J R. Relationship between structure and mechanical function of the tissues of the intervertebral joint[J]. Integr Comp Biol,2000,40(1):42-52.
[8] 杨正汉,赵继荣,马俊飞,等. 生长因子在椎间盘退变中的作用及中医药干预研究进展[J]. 中国现代医学杂志,2023,33(23):78-84.
[9] CHAN W C,SZE K L,SAMARTZIS D,et al. Structure and biology of the intervertebral disk in health and disease[J]. Orthop Clin North Am,2011,42(4):447-464,vii.
[10] URBAN J P,ROBERTS S.Degeneration of the intervertebral disc[J]. Arthritis Res Ther,2003,5(3):120-130.
[11] BOOS N,WEISSBACH S,ROHRBACH H,et al.Classification of age-related changes in lumbar intervertebral discs:2002 Volvo Award in basic science[J]. Spine,2002,27(23):2631-2644.
[12] WUERTZ K,HAGLUND L.Inflammatory mediators in intervertebral disk degeneration and discogenic pain[J]. Global Spine J,2013,3(3):175-184.
[13] MEACHAM K,SHEPHERD A,MOHAPATRA D P,et al.Neuropathic pain:central vs. peripheral mechanisms[J]. Curr Pain Headache Rep,2017,21(6):28.
[14] PENG B G,HAO J H,HOU S X,et al.Possible pathogenesis of painful intervertebral disc degeneration[J]. Spine,2006,31(5):560-566.
[15] 李土胜,丁宇,蒋强,等. 腰椎间盘源性神经痛免疫复合物表达及富血小板血浆的治疗机制[J]. 中国组织工程研究,2023,27(18):2935-2942.
[16] BARBIR A,GODBURN K E,MICHALEK A J,et al.Effects of torsion on intervertebral disc gene expression and biomechanics,using a rat tail model[J]. Spine (Phila Pa 1976),2011,36(8):607-614.
[17] DUDLI S,HASCHTMANN D,FERGUSON S J.Fracture of the vertebral endplates,but not equienergetic impact load,promotes disc degeneration in vitro[J]. J Orthop Res,2012,30(5):809-816.
[18] 谢芋涛,王想福,石瑞芳,等. 中药调控NF-κB信号通路干预椎间盘退行性变的作用机制[J]. 中医学报,2024,39(4):737-742.
[19] 沈锋,刘观燚. 椎间盘源性腰痛的研究进展[J]. 中国骨与关节损伤杂志,2021,36(9):1002-1004.
[20] WANG L B,HE T,LIU J K,et al.Revealing the immune infiltration landscape and identifying diagnostic biomarkers for lumbar disc herniation[J]. Front Immunol,2021,12:666355.
[21] NICO B,MANGIERI D,BENAGIANO V,et al.Nerve growth factor as an angiogenic factor[J]. Microvasc Res,2008,75(2):135-141.
[22] 冯阳,严旭,王永魁,等. 腰椎间盘退变性疾病与外周血淋巴细胞亚群的关系[J]. 中国组织工程研究,2020,24(17):2630-2635.
[23] MALCANGIO M.Role of the immune system in neuropathic pain[J]. Scand J Pain,2019,20(1):33-37.
[24] TOZAKI-SAITOH H,TSUDA M.Microglia-neuron interactions in the models of neuropathic pain[J]. Biochem Pharmacol,2019,169:113614.
[25] 王艺璇,李水清,孟秀丽. 富血小板血浆治疗慢性腰背痛的研究进展[J]. 中国微创外科杂志,2022,22(5):421-424.
[26] 栾烁,阮玉婷,栗晓,等. 富血小板血浆修复重建退变腰椎间盘组织的基础与临床研究进展[J]. 解剖学研究,2017,39(6):487-490.
[27] 阚厚铭,范利君,陈学泰,等. 富血小板血浆在神经病理性疼痛中的应用[J]. 中国组织工程研究,2022,26(8):1345-1353.
[28] CHANG N J,ERDENEKHUYAG Y,CHOU P H,et al.Therapeutic effects of the addition of platelet-rich plasma to bioimplants and early rehabilitation exercise on articular cartilage repair[J]. Am J Sports Med,2018,46(9):2232-2241.
[29] HAGIHARA M,HIGUCHI A,TAMURA N,et al.Platelets,after exposure to a high shear stress,induce IL-10-producing,mature dendritic cells in vitro[J]. J Immunol,2004,172(9):5297-5303.
[30] 孙阳,李小飞,马胜山,等. 富血小板血浆治疗椎间盘退变的研究进展[J]. 中国脊柱脊髓杂志,2020,30(8):762-766.
[31] ZHENG C B,ZHU Q T,LIU X L,et al.Effect of platelet-rich plasma (PRP) concentration on proliferation,neurotrophic function and migration of Schwann cells in vitro[J]. J Tissue Eng Regen Med,2016,10(5):428-436.
[32] BORHANI-HAGHIGHI M,MOHAMADI Y.The therapeutic effect of platelet-rich plasma on the experimental autoimmune encephalomyelitis mice[J]. J Neuroimmunol,2019,333:476958.
[33] YE F G,LI H Y,QIAO G X,et al.Platelet-rich plasma gel in combination with Schwann cells for repair of sciatic nerve injury[J]. Neural Regen Res,2012,7(29):2286-2292.
[34] OGUNDELE O M,PARDO J,FRANCIS J,et al.A putative mechanism of age-related synaptic dysfunction based on the impact of IGF-1 receptor signaling on synaptic CaMKIIα phosphorylation[J]. Front Neuroanat,2018,12:35.
[35] 姜壮,王华松,丰瑞兵,等. 生长因子在骨折愈合过程中的作用及其机制的研究进展[J]. 华南国防医学杂志,2020,34(11):823-827.
[36] LAI F Y,KAKUDO N,MORIMOTO N,et al.Platelet-rich plasma enhances the proliferation of human adipose stem cells through multiple signaling pathways[J]. Stem Cell Res Ther,2018,9(1):107.
[37] TUAKLI-WOSORNU Y A,TERRY A,BOACHIE-ADJEI K,et al. Lumbar intradiskal platelet-rich plasma (PRP) injections:a prospective,double-blind,randomized controlled study[J]. PM R,2016,8(1):1-10;quiz 10.
[38] MISHRA A,WOODALL J,VIEIRA A.Treatment of tendon and muscle using platelet-rich plasma[J]. Clin Phys Med,2009,28(1):113-125.
[39] SAMPSON S,GERHARDT M,MANDELBAUM B.Platelet rich plasma injection grafts for musculoskeletal injuries:a review[J]. Curr Rev Musculoskelet Med,2008,1(3/4):165-174.
[40] 曾淑红,易成刚. 血小板浓缩提取物促进组织修复的研究进展[J]. 中国美容整形外科杂志,2021,32(12):768.
[41] RAWSON B.Platelet-rich plasma and epidural platelet lysate:novel treatment for lumbar disk herniation[J]. J Am Osteopath Assoc,2020,120(3):201-207.
[42] 郭瑛,贾连顺,黄智. 自体富血小板血浆在脊柱外科治疗中的应用[J]. 中国组织工程研究,2017,21(27):4403-4408.
[43] PODD D.Platelet-rich plasma therapy:origins and applications investigated[J]. JAAPA,2012,25(6):44-49.
[44] CHENG J,SANTIAGO K A,NGUYEN J T,et al.Treatment of symptomatic degenerative intervertebral discs with autologous platelet-rich plasma:follow-up at 5-9years[J]. Regen Med,2019,14(9):831-840.
[45] JAIN D,GOYAL T,VERMA N,et al.Intradiscal platelet-rich plasma injection for discogenic low back pain and correlation with platelet concentration:a prospective clinical trial[J]. Pain Med,2020,21(11):2719-2725.
[46] LUTZ C,CHENG J,PRYSAK M,et al.Clinical outcomes following intradiscal injections of higher-concentration platelet-rich plasma in patients with chronic lumbar discogenic pain[J]. Int Orthop,2022,46(6):1381-1385.
[47] AKEDA K,OHISHI K,MASUDA K,et al.Intradiscal injection of autologous platelet-rich plasma releasate to treat discogenic low back pain:a preliminary clinical trial[J]. Asian Spine J,2017,11(3):380-389.
[48] AKEDA K,OHISHI K,TAKEGAMI N,et al.Platelet-rich plasma releasate versus corticosteroid for the treatment of discogenic low back pain:a double-blind randomized controlled trial[J]. J Clin Med,2022,11(2):304.
[49] 张建波,陈金生,宫庆娟,等. 椎间盘内注射富血小板血浆与射频热凝治疗盘源性腰痛的疗效比较[J]. 中国疼痛医学杂志,2022,28(7):515-521.
[50] CAO Z L,XU H,WU J Q,et al.The clinical efficacy of autologous platelet-rich plasma interventional circulatory perfusion combined with radiofrequency ablation and thermocoagulation in the treatment of discogenic low back pain[J]. Int J Clin Pract,2023,2023:1489905.
[51] 中国输血协会临床输血管理学专业委员会. 自体单采富血小板血浆关节腔注射治疗膝骨关节炎的专家共识[J]. 中国输血杂志,2022,35(12):1187-1194.
[52] 邢丹,余楠生,张长青. 《关节腔注射富血小板血浆治疗膝骨关节炎的临床实践指南(2018年版)》推荐意见解读及方法学评价[J]. 中华关节外科杂志(电子版),2018,12(4):449-453.
[53] 袁霆,张长青,余楠生. 富血小板血浆在骨关节外科临床应用专家共识(2018年版)[J]. 中华关节外科杂志(电子版),2018,12(5):596-600.

Research Progress of Autologous Platelet-rich Plasma in Treatment of Discogenic Low Back Pain

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