Blood Agglutination Phenomenon in COVID-19 Infection

doi:10.3969/j.issn.1671-2587.2025.03.022

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2025, Vol. 27 ›› Issue (3): 423-426.DOI: 10.3969/j.issn.1671-2587.2025.03.022

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Blood Agglutination Phenomenon in COVID-19 Infection

LIAO Yuanmeng, HE Yuan

Department of Laboratory Medicine, First Affiliated Hospital of Army Medical University 400038

Received:2024-11-25 Published:2025-06-23

Abstract

Abstract: The coronavirus disease (COVID-19) is a severe respiratory infectious disease caused by the SARS-CoV-2 virus. It can cause multiple system diseases beyond the respiratory system. The phenomenon of cold agglutination in blood can be seen in routine tests or crossmatching in some COVID-19 patients, and it has an increasing trend in the peak epidemic period. This is characterized by increased cold agglutinin titers and blood agglutination, and a few patients develop cold agglutinin syndrome and hemolytic reactions. The cold agglutinin can significantly affect blood routine parameters. A thorough understanding of the mechanism and characteristics of cold agglutination after SARS-CoV-2 infection, as well as the correction of test results from blood cold agglutination samples, can provide more accurate results for clinical practice. This article will review the relevant research progress on cold agglutination in blood during SARS-CoV-2 infection.

Key words: Cold agglutinin, Cold agglutination phenomenon, COVID-19

CLC Number:

R512.99R446.11

LIAO Yuanmeng, HE Yuan. Blood Agglutination Phenomenon in COVID-19 Infection[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(3): 423-426.

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Blood Agglutination Phenomenon in COVID-19 Infection

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