Effect of Platelet-rich Fibrin on Wound Repair of Intrauterine Adhesions

doi:10.3969/j.issn.1671-2587.2022.03.018

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2022, Vol. 24 ›› Issue (3): 363-368.DOI: 10.3969/j.issn.1671-2587.2022.03.018

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Effect of Platelet-rich Fibrin on Wound Repair of Intrauterine Adhesions

YANG Mu-kun, WANG Zi-jun, CUI Guang-xia, et al

Department of Obstetrics and Gynecology,Beijing Shijitan Hospital,Capital Medical University 100038

Received:2022-04-29 Online:2022-06-20 Published:2022-06-22

Abstract

Abstract: Objective To evaluate the morphological effects of Platelet-rich fibrin （PRF） on wound repair of intrauterine adhesion. Methods 68 patients with intrauterine adhesions were randomly divided into PRF group and control group by 1∶1. All patients received TCRA and took endometrial tissue. PRF was injected into intrauterine immediately and 4 weeks after TCRA in PRF group,while no drug was used in control group. 8 weeks later,the two groups underwent second hysteroscopy. Endometrial morphologic changes were evaluated 8 weeks after treatment. Results In PRF group,the number of endometrial glands,Ki67,Cytokeratin 18（CK-18）,Vimentin average fluorescence intensity increased after treatment,and the proportion of fibrosis area decreased. The number of endometrial glands and average fluorescence intensity of Ki67 in PRF group were significantly higher than those in control group（P<0.05）. The proportion of fibrotic area was smaller than that of control group（P<0.01）. Conclusion PRF treatment can significantly promote wound repair after intrauterine operation.

Key words: Intrauterine adhesions, Platelet-rich fibrin, Growth factor, Wound repair

CLC Number:

R711.74

YANG Mu-kun, WANG Zi-jun, CUI Guang-xia, et al. Effect of Platelet-rich Fibrin on Wound Repair of Intrauterine Adhesions[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24(3): 363-368.

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Effect of Platelet-rich Fibrin on Wound Repair of Intrauterine Adhesions

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