The Prospect of Combined Application of Platelet-rich Plasma and Mesenchymal Stem Cells in Regenerative Medicine

doi:10.3969/j.issn.1671-2587.2024.03.020

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2024, Vol. 26 ›› Issue (3): 420-426.DOI: 10.3969/j.issn.1671-2587.2024.03.020

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The Prospect of Combined Application of Platelet-rich Plasma and Mesenchymal Stem Cells in Regenerative Medicine

ZHAO Ziyue, HUANG Weihua, CHA Zhanshan

Department of Blood Transfusion, Changhai Hospital, The First Affiliated Hospital of PLA Naval Medical University 200433

Received:2024-02-08 Online:2024-06-20 Published:2024-06-24

Abstract

Abstract: The combined application of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) has shown great potential in regenerative medicine, providing new therapeutic strategies and powerful tools for the treatment of various diseases and tissue regeneration. This combined application combines the abundant growth factors in PRP and the multidirectional differentiation potential of MSCs to produce a synergistic effect that accelerate tissue regeneration and repair processes. The combined application of PRP and MSCs in different medical fields, such as orthopedics, orthopedics, cardiovascular and infertility treatment, has shown a wide range of application potential. In addition, personalized medicine has been made possible to adjust the treatment plan according to the specific situation of the patient and improve the treatment effect. However, there are some risks and limitations in the process. Among them, the risks of uncontrolled differentiation, bleeding and thrombosis require to be payed specialattention. In addition, the long-term safety, persistence of effects, and standardization of treatment protocols remain uncertain and need to be verified by more large-scale studies. In summary, the combined application of PRP and MSCs brings new hope and prospects for the field of regenerative medicine, but the advantages and risks need to be carefully weighed to ensure the safety and effectiveness of treatment options.

Key words: Platelet-rich plasma, Mesenchymal stem cells, Regenerative medicine

CLC Number:

R457.1

ZHAO Ziyue, HUANG Weihua, CHA Zhanshan. The Prospect of Combined Application of Platelet-rich Plasma and Mesenchymal Stem Cells in Regenerative Medicine[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2024, 26(3): 420-426.

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The Prospect of Combined Application of Platelet-rich Plasma and Mesenchymal Stem Cells in Regenerative Medicine

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