Progress in Detection Technologies for Bacterial Pathogens in Platelets

doi:10.3969/j.issn.1671-2587.2025.05.013

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2025, Vol. 27 ›› Issue (5): 667-673.DOI: 10.3969/j.issn.1671-2587.2025.05.013

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Progress in Detection Technologies for Bacterial Pathogens in Platelets

MA Jingsi, ZHAO Ning, DENG Jiang, ZHANG Yanyu

Military Medical Research Institute, Beijing 100850

Received:2025-09-01 Revised:2025-09-09 Online:2025-10-20 Published:2025-10-11

Abstract

Abstract: Platelet products are crucial components in clinical blood transfusion. However, their storage under conventional conditions (22±2) ℃ is prone to bacterial contamination, which poses a risk of sepsis and constitutes one of the core challenges to blood transfusion safety. This review aims to summarize the research progress of bacterial detection technologies for platelets. First, the article analyzes the advantages and disadvantages of traditional detection methods represented by automated microbial culture systems, as well as the performance merits and demerits of various emerging technologies, including nucleic acid amplification technology, immunoassay, flow cytometry, mass spectrometry, metagenomics, surface-enhanced Raman spectroscopy, and nanobiosensors. Subsequently, it elaborates on the core challenges currently faced and provides an outlook on future development trends.Ultimately, this review intends to offer a scientific basis for establishing a more comprehensive quality and safety assurance system for platelets.

Key words: Platelet, Bacterial contamination, Detection technology, Blood transfusion safety

CLC Number:

R446.5

MA Jingsi, ZHAO Ning, DENG Jiang, ZHANG Yanyu. Progress in Detection Technologies for Bacterial Pathogens in Platelets[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(5): 667-673.

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Progress in Detection Technologies for Bacterial Pathogens in Platelets

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