Abstract: Objective To investigate the genetic polymorphisms of Dombrock blood group in Zhuang nationality population in different areas of Guangxi. Methods We analyzed the genotypes of Dombrock blood group in 1 025 non-related Guangxi Zhuang nationality population who live in Wuming, Shanglin, Longan, Binyang, Pingguo, Dahua, Duan, Bama, and Daxin by PCR-SSP typing. Results Three individuals were found to carry Do^a(+) homozygote, while 865 cases have Do^b(+) homozygote. The Do^a gene frequencies of Wuming, Shanglin, Longan, Binyang, Pingguo, Dahua, Duan, Bama, and Daxin was 0.090 9, 0.045 9, 0.090 9, 0.062 5, 0.108 3, 0.054 2, 0.091 7, 0.066 7 and 0.100 0, respectively. The general gene frequency of Do^a was 0.079 5,while that of Dob was 0.920 5. Conclusion The distribution feature of Dombrock blood group in Guangxi Zhuang nationality was polymorphic, which is similar to that in Chinese Han population. Do^a gene frequency in the population studied, however, is much lower than that in Tibetan and Uyghur nationality.

Key words: Guangxi Zhuang nationality, Dombrock blood group, Gene frequency, PCR-SSP