Abstract: Objective To investigate the clinical application of homocysteine in the interventional treatment of myocardial infarction. Method 156 patients cured in our hospital treated by percutaneous coronary intervention with acute myocardial infarction from 2014 June to 2016 January were chosen as the treatment group,before and after treatment hyperlipidemia,homocysteine and other indicators were detected and compared with 60 healthy persons （the control group）. Results The levels of blood pressure、BMI、TG、TC、LDL-C、HDL-C、GLU and Hcy in the treatment group before the operation were higher than the control group,the difference was statistically significant （P<0.05）; The levels of Hcy in the treatment group after the operation were lower than before the operation,but higher than the control group,the difference was statistically significant（P<0.05）; multivariate Logistic regression analysis showed that Hcy was an independent risk factor for AMI. Conclusion The Hcy level decreased after acute myocardial infarction PCI,is related to the severity of coronary heart disease,it is helpful to understand the condition and prognosis of myocardial infarction.

Key words: Interventional treatment, Homocysteine, Myocardial infarction