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临床输血与检验

临床输血与检验 ›› 2016, Vol. 18 ›› Issue (5): 478-481.DOI: 10.3969/j.issn.1671-2587.2016.05.025

• 临床检验研究 • 上一篇    下一篇

血清HE4联合CA125检测在卵巢癌早期诊断及预后评估中的临床价值

陈琪   

  1. 214000 江苏省无锡市妇幼保健院检验科
  • 收稿日期:2016-04-25 出版日期:2016-10-20 发布日期:2017-05-19
  • 作者简介:陈琪（1987-）,女,江苏无锡人,检验医师,学士,主要从事妇产科检验工作,（E-mail）chenqi401871@163.com。

Clinical Value of Serum HE4 Combined with CA125 Detection in Early Diagnosis and Prognosis of Ovarian Cancer

CHEN Qi   

  1. Wuxi Maternal and Child Health-Care Hospital 214000
  • Received:2016-04-25 Online:2016-10-20 Published:2017-05-19

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摘要： 目的 探究血清HE4联合CA125检测在卵巢癌早期诊断及预后评估中的临床价值。方法 选取2014年1月~2015年4月在本院进行卵巢癌治疗的72例患者,开展血清HE4联合CA125检测。比较患者单项检测与联合检测后的血清HE4、CA125水平表达情况、不同病理因素下表达情况及其对患者治疗后生存时间的影响,探究血清HE4联合CA125检测在卵巢癌早期诊断及预后评估中的临床价值。结果 与正常人群比较,卵巢癌患者血清HE4、CA125明显升高（P<0.05）;HE4、CA125单项检测的灵敏度、特异度、阳性预测率、阴性预测率明显低于联合检测;此外,采用HE4联合CA125检测的漏诊率比单项检测更低,约登指数更高（P<0.05）;通过血清HE4联合CA125检测的患者治疗后死亡例数明显少于单项检测的例数（P<0.05）。结论 血清HE4联合CA125检测能够有效分析患者的疾病类型以及找出病理因素,并预测患者的生存时间,具有较高的临床价值。

关键词: 血清HE4, 血清CA125, 卵巢癌, 预后评估, 早期诊断

Abstract: Objective To explore the clinical significance of serum HE4 combined with CA125 detections in early diagnosis and prognosis in evaluation of ovarian cancer. Methods Seventy-two cases of colon cancer treated in hospital from January 2014 to April 2015 were followed up,and serum HE4 and CA125 were jointly detected. The expression of CA125 and HE4 in the patients with single or combined tests was compared, and the pathological changes and survival duration of the patients were analyzed for the clinical significance of HE4 with CA125 detection in early diagnosis and prognosis evaluation of ovarian cancer. Results Serum HE4 and CA125 levels were significantly higher in ovarian cancer patients（P<0.05） compared with the normal. Sensitivity,specificity,positive or negative predictive rate were obviously lower in HE4 or CA125 single test. The combined tests of HE4 and CA125 gave rise to a low missed diagnosis and a high Youden index（P<0.05）. The motality of patients treated under orientation of both HE4 combined with CA 125 detection was significantly less than that of the single detection（P<0.05）. Conclusion Serum HE4 combined with CA125 detection can effectively predict the survival lenghth of patients,and has a high clinical value.

Key words: Serum HE4, Serum CA125, Ovarian carcinoma, Prognosis evaluation, Early diagnosis

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